Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000522907> ?p ?o ?g. }
- W2000522907 endingPage "e67649" @default.
- W2000522907 startingPage "e67649" @default.
- W2000522907 abstract "An incomplete understanding of bone forming cells during wound healing and ectopic calcification has led to a search for circulating cells that may fulfill this function. Previously, we showed that monoosteophils, a novel lineage of calcifying/bone-forming cells generated by treatment of monocytes with the natural peptide LL-37, are candidates. In this study, we have analyzed their gene expression profile and bone repair function.Human monoosteophils can be distinguished from monocytes, macrophages and osteoclasts by their unique up-regulation of integrin α3 and down-regulation of CD14 and CD16. Monoosteophils express high mRNA and protein levels of SPP1 (osteopontin), GPNMB (osteoactivin), CHI3L1 (cartilage glycoprotein-39), CHIT1 (Chitinase 1), MMP-7, CCL22 and MAPK13 (p38MAPKδ). Monocytes from wild type, but not MAPK13 KO mice are also capable of monoosteophil differentiation, suggesting that MAPK13 regulates this process. When human monoosteophils were implanted in a freshly drilled hole in mid-diaphyseal femurs of NOD/SCID mice, significant bone repair required only 14 days compared to at least 24 days in control treated injuries.Human derived monoosteophils, characterized as CD45(+)α3(+)α3β(+)CD34(-)CD14(-)BAP (bone alkaline phosphatase)(-) cells, can function in an animal model of bone injury." @default.
- W2000522907 created "2016-06-24" @default.
- W2000522907 creator A5016834515 @default.
- W2000522907 creator A5065940864 @default.
- W2000522907 date "2013-07-03" @default.
- W2000522907 modified "2023-10-06" @default.
- W2000522907 title "Acceleration of Bone Repair in NOD/SCID Mice by Human Monoosteophils, Novel LL-37-Activated Monocytes" @default.
- W2000522907 cites W1485073457 @default.
- W2000522907 cites W1487373628 @default.
- W2000522907 cites W1865554598 @default.
- W2000522907 cites W1900312847 @default.
- W2000522907 cites W1964758221 @default.
- W2000522907 cites W1975576405 @default.
- W2000522907 cites W1978271794 @default.
- W2000522907 cites W1991881823 @default.
- W2000522907 cites W1992239128 @default.
- W2000522907 cites W1996487637 @default.
- W2000522907 cites W1996752963 @default.
- W2000522907 cites W2000624726 @default.
- W2000522907 cites W2007352125 @default.
- W2000522907 cites W2010409614 @default.
- W2000522907 cites W2032940634 @default.
- W2000522907 cites W2041091710 @default.
- W2000522907 cites W2048299560 @default.
- W2000522907 cites W2052673490 @default.
- W2000522907 cites W2055020316 @default.
- W2000522907 cites W2064729399 @default.
- W2000522907 cites W2065067981 @default.
- W2000522907 cites W2065940152 @default.
- W2000522907 cites W2068557721 @default.
- W2000522907 cites W2081719489 @default.
- W2000522907 cites W2086671663 @default.
- W2000522907 cites W2094326057 @default.
- W2000522907 cites W2097766446 @default.
- W2000522907 cites W2102614398 @default.
- W2000522907 cites W2104363348 @default.
- W2000522907 cites W2105323385 @default.
- W2000522907 cites W2111148911 @default.
- W2000522907 cites W2113697838 @default.
- W2000522907 cites W2126441181 @default.
- W2000522907 cites W2131350538 @default.
- W2000522907 cites W2133169277 @default.
- W2000522907 cites W2135046649 @default.
- W2000522907 cites W2140170107 @default.
- W2000522907 cites W2142551142 @default.
- W2000522907 cites W2145639716 @default.
- W2000522907 cites W2165529185 @default.
- W2000522907 cites W2169759699 @default.
- W2000522907 cites W2170983988 @default.
- W2000522907 cites W261597661 @default.
- W2000522907 doi "https://doi.org/10.1371/journal.pone.0067649" @default.
- W2000522907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3701041" @default.
- W2000522907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23844045" @default.
- W2000522907 hasPublicationYear "2013" @default.
- W2000522907 type Work @default.
- W2000522907 sameAs 2000522907 @default.
- W2000522907 citedByCount "19" @default.
- W2000522907 countsByYear W20005229072014 @default.
- W2000522907 countsByYear W20005229072016 @default.
- W2000522907 countsByYear W20005229072017 @default.
- W2000522907 countsByYear W20005229072019 @default.
- W2000522907 countsByYear W20005229072020 @default.
- W2000522907 countsByYear W20005229072021 @default.
- W2000522907 countsByYear W20005229072022 @default.
- W2000522907 countsByYear W20005229072023 @default.
- W2000522907 crossrefType "journal-article" @default.
- W2000522907 hasAuthorship W2000522907A5016834515 @default.
- W2000522907 hasAuthorship W2000522907A5065940864 @default.
- W2000522907 hasBestOaLocation W20005229071 @default.
- W2000522907 hasConcept C105702510 @default.
- W2000522907 hasConcept C131075544 @default.
- W2000522907 hasConcept C134018914 @default.
- W2000522907 hasConcept C153911025 @default.
- W2000522907 hasConcept C160160445 @default.
- W2000522907 hasConcept C170493617 @default.
- W2000522907 hasConcept C181199279 @default.
- W2000522907 hasConcept C185592680 @default.
- W2000522907 hasConcept C203014093 @default.
- W2000522907 hasConcept C2776033226 @default.
- W2000522907 hasConcept C2778513237 @default.
- W2000522907 hasConcept C2780007613 @default.
- W2000522907 hasConcept C2780804394 @default.
- W2000522907 hasConcept C2781078528 @default.
- W2000522907 hasConcept C2781184567 @default.
- W2000522907 hasConcept C2781460891 @default.
- W2000522907 hasConcept C553184892 @default.
- W2000522907 hasConcept C55493867 @default.
- W2000522907 hasConcept C555293320 @default.
- W2000522907 hasConcept C55851684 @default.
- W2000522907 hasConcept C8337478 @default.
- W2000522907 hasConcept C86803240 @default.
- W2000522907 hasConcept C95444343 @default.
- W2000522907 hasConceptScore W2000522907C105702510 @default.
- W2000522907 hasConceptScore W2000522907C131075544 @default.
- W2000522907 hasConceptScore W2000522907C134018914 @default.
- W2000522907 hasConceptScore W2000522907C153911025 @default.
- W2000522907 hasConceptScore W2000522907C160160445 @default.
- W2000522907 hasConceptScore W2000522907C170493617 @default.