FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000523053> ?p ?o ?g. }

• W2000523053 endingPage "18462" @default.
• W2000523053 startingPage "18457" @default.
• W2000523053 abstract "To begin to elucidate the principles of intermolecular dynamics in the crowded environment of cells, employing Brownian dynamics (BD) simulations, we examined possible mechanism(s) responsible for the great reduction in diffusion constants of macromolecules in vivo from that at infinite dilution. In an Escherichia coli cytoplasm model comprised of 15 different macromolecule types at physiological concentrations, BD simulations of molecular-shaped and equivalent sphere representations were performed with a soft repulsive potential. At cellular concentrations, the calculated diffusion constant of GFP is much larger than experiment, with no significant shape dependence. Next, using the equivalent sphere system, hydrodynamic interactions (HI) were considered. Without adjustable parameters, the in vivo experimental GFP diffusion constant was reproduced. Finally, the effects of nonspecific attractive interactions were examined. The reduction in diffusivity is very sensitive to macromolecular radius with the motion of the largest macromolecules dramatically slowed down; this is not seen if HI dominate. In addition, long-lived clusters involving the largest macromolecules form if attractions dominate, whereas HI give rise to significant, size independent intermolecular dynamic correlations. These qualitative differences provide a testable means of differentiating the importance of HI vs. nonspecific attractive interactions on macromolecular motion in cells." @default.
• W2000523053 created "2016-06-24" @default.
• W2000523053 creator A5010808261 @default.
• W2000523053 creator A5014448041 @default.
• W2000523053 date "2010-10-11" @default.
• W2000523053 modified "2023-10-16" @default.
• W2000523053 title "Crowding and hydrodynamic interactions likely dominate in vivo macromolecular motion" @default.
• W2000523053 cites W1565036272 @default.
• W2000523053 cites W1709650666 @default.
• W2000523053 cites W1771027239 @default.
• W2000523053 cites W1966400587 @default.
• W2000523053 cites W1968478348 @default.
• W2000523053 cites W1976488701 @default.
• W2000523053 cites W1981410769 @default.
• W2000523053 cites W1981608015 @default.
• W2000523053 cites W1986482900 @default.
• W2000523053 cites W1986606329 @default.
• W2000523053 cites W1989925383 @default.
• W2000523053 cites W1994787881 @default.
• W2000523053 cites W1994861434 @default.
• W2000523053 cites W1999187172 @default.
• W2000523053 cites W2008832313 @default.
• W2000523053 cites W2009005140 @default.
• W2000523053 cites W2011450733 @default.
• W2000523053 cites W2013931680 @default.
• W2000523053 cites W2020388573 @default.
• W2000523053 cites W2023269994 @default.
• W2000523053 cites W2029667189 @default.
• W2000523053 cites W2030695915 @default.
• W2000523053 cites W2032655419 @default.
• W2000523053 cites W2036911691 @default.
• W2000523053 cites W2046058559 @default.
• W2000523053 cites W2046663303 @default.
• W2000523053 cites W2052112948 @default.
• W2000523053 cites W2054241952 @default.
• W2000523053 cites W2054655080 @default.
• W2000523053 cites W2067694199 @default.
• W2000523053 cites W2068359975 @default.
• W2000523053 cites W2070129612 @default.
• W2000523053 cites W2074171558 @default.
• W2000523053 cites W2078472083 @default.
• W2000523053 cites W2079122045 @default.
• W2000523053 cites W2080562735 @default.
• W2000523053 cites W2089102241 @default.
• W2000523053 cites W2102612168 @default.
• W2000523053 cites W2104547497 @default.
• W2000523053 cites W2124452214 @default.
• W2000523053 cites W2131187223 @default.
• W2000523053 cites W2144347309 @default.
• W2000523053 cites W2148192047 @default.
• W2000523053 cites W2150766477 @default.
• W2000523053 cites W2151383814 @default.
• W2000523053 cites W2152607628 @default.
• W2000523053 cites W2163126094 @default.
• W2000523053 cites W2165360511 @default.
• W2000523053 cites W2166317344 @default.
• W2000523053 cites W2168667184 @default.
• W2000523053 cites W2170471837 @default.
• W2000523053 cites W2171437582 @default.
• W2000523053 cites W2171539493 @default.
• W2000523053 cites W4247469229 @default.
• W2000523053 cites W4252832327 @default.
• W2000523053 doi "https://doi.org/10.1073/pnas.1011354107" @default.
• W2000523053 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2973006" @default.
• W2000523053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20937902" @default.
• W2000523053 hasPublicationYear "2010" @default.
• W2000523053 type Work @default.
• W2000523053 sameAs 2000523053 @default.
• W2000523053 citedByCount "355" @default.
• W2000523053 countsByYear W20005230532012 @default.
• W2000523053 countsByYear W20005230532013 @default.
• W2000523053 countsByYear W20005230532014 @default.
• W2000523053 countsByYear W20005230532015 @default.
• W2000523053 countsByYear W20005230532016 @default.
• W2000523053 countsByYear W20005230532017 @default.
• W2000523053 countsByYear W20005230532018 @default.
• W2000523053 countsByYear W20005230532019 @default.
• W2000523053 countsByYear W20005230532020 @default.
• W2000523053 countsByYear W20005230532021 @default.
• W2000523053 countsByYear W20005230532022 @default.
• W2000523053 countsByYear W20005230532023 @default.
• W2000523053 crossrefType "journal-article" @default.
• W2000523053 hasAuthorship W2000523053A5010808261 @default.
• W2000523053 hasAuthorship W2000523053A5014448041 @default.
• W2000523053 hasBestOaLocation W20005230532 @default.
• W2000523053 hasConcept C112401455 @default.
• W2000523053 hasConcept C121332964 @default.
• W2000523053 hasConcept C12554922 @default.
• W2000523053 hasConcept C130603088 @default.
• W2000523053 hasConcept C147597530 @default.
• W2000523053 hasConcept C150903083 @default.
• W2000523053 hasConcept C159467904 @default.
• W2000523053 hasConcept C166950319 @default.
• W2000523053 hasConcept C178635117 @default.
• W2000523053 hasConcept C178790620 @default.
• W2000523053 hasConcept C181990884 @default.
• W2000523053 hasConcept C185592680 @default.
• W2000523053 hasConcept C187128312 @default.

• next