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- W2000524238 abstract "The effect of amidinonaphthol derivatives on platelet aggregation was investigated. Platelet aggregation was affected, and the aggregated platelets were dispersed by addition of the derivatives after stimulation. The agents produced dose-dependent inhibition of fibrinogen and fibronectin binding to ADP, and thrombin stimulated living or fixed platelets at the same dose range. Moreover, the bound ligand was displaced from platelets by the agents. The capacity of the derivatives to inhibit binding to cells with an expressed receptor, i.e. fixed platelets, and to dissociate the bound ligand from platelets, excludes an effect on receptor induction, and was similar to that of the arginyl-glycyl-aspartate (RGD) peptide. Chemical cross-linking approach of the RGD peptide to ADP-stimulated platelets revealed that cross-linking of the peptide to platelet glycoprotein IIIa was inhibited by the derivatives. These results indicated that amidinonaphthol derivatives directly affect the RGD binding sites of glycoprotein IIIa, or another mutually exclusive site." @default.
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- W2000524238 date "1995-09-01" @default.
- W2000524238 modified "2023-09-27" @default.
- W2000524238 title "Amidinonaphthol derivatives directly inhibit the ligand binding on platelet glycoprotein IIb–IIIa" @default.
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- W2000524238 doi "https://doi.org/10.1016/0928-4680(95)00027-x" @default.
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