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• W2000524781 abstract "Multiple studies demonstrate that there is a period of development of rheumatoid arthritis (RA) during which there are elevations of disease-related biomarkers, including autoantibodies, in the absence of and prior to the development of RA; this period can be termed ‘preclinical RA’. These ‘preclinical’ autoantibodies including rheumatoid factor and antibodies to citrullinated protein antigens, and more recent studies have also identified additional autoantibodies and a wide range of inflammatory biomarkers. These findings in conjunction with established and emerging data about genetic and environmental risk factors for RA support a model of disease development where certain factors lead to an initial triggering of RA-related autoimmunity that expands over time to the point where symptomatic arthritis classifiable as RA develops. Herein will be reviewed updates in the field, as well as a discussion of current limitations of our understanding of preclinical RA, and potential future directions for study." @default.
• W2000524781 created "2016-06-24" @default.
• W2000524781 creator A5011051142 @default.
• W2000524781 date "2014-03-19" @default.
• W2000524781 modified "2023-10-11" @default.
• W2000524781 title "Preclinical Rheumatoid Arthritis (Autoantibodies): An Updated Review" @default.
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• W2000524781 doi "https://doi.org/10.1007/s11926-014-0419-6" @default.
• W2000524781 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4059414" @default.
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