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• W2000526237 abstract "RATIONALE: An epidemic of asthma exacerbations in children occurs annually following school return after summer vacation.METHODS: In a double blind randomized placebo-controlled trial, 194 children aged 2-14 stratified by age and sex added montelukast or placebo to usual therapy between September 1 and October 15 2005. Entry criteria included; physician diagnosed asthma; rescue inhaler needed in the last year; school absence due to asthma in the last year; history of asthma exacerbations associated with apparent respiratory viral infections.RESULTS: A 53% reduction in days with worse asthma symptoms occurred with montelukast compared to placebo, (3.9% versus 8.3%, p<.02), and a 78% reduction in unscheduled physician visits for asthma (4 versus 18, p = .011). The benefit of montelukast occurred both in those using and not using regular inhaled corticosteroids. Boys 2-5 years showed the greatest benefit from montelukast, (0.4% versus 8.8% days with worse asthma symptoms, p<.001), with a lesser effect among 6-9 year olds (2.0% montelukast versus 7.0% placebo, p = .12), and a minimal effect in 10-14 year olds (6.3% montelukast versus 8.2% placebo, p = 0.44). In girls the treatment effect was minimal in 2-5 year olds (5.7% with montelukast, 6.9% with placebo) and in 6-9 year olds (4.5% vs. 4.6%) but strong and significant in 10-14 year olds (4.6 % with montelukast versus17.0% with placebo, p = 0.03).CONCLUSION: Montelukast added to usual treatment substantially reduced the risk of worsening asthma symptoms and unscheduled physician visits during the September asthma epidemic. Treatment effect differences observed between age and sex groups require further investigation in future studies. RATIONALE: An epidemic of asthma exacerbations in children occurs annually following school return after summer vacation. METHODS: In a double blind randomized placebo-controlled trial, 194 children aged 2-14 stratified by age and sex added montelukast or placebo to usual therapy between September 1 and October 15 2005. Entry criteria included; physician diagnosed asthma; rescue inhaler needed in the last year; school absence due to asthma in the last year; history of asthma exacerbations associated with apparent respiratory viral infections. RESULTS: A 53% reduction in days with worse asthma symptoms occurred with montelukast compared to placebo, (3.9% versus 8.3%, p<.02), and a 78% reduction in unscheduled physician visits for asthma (4 versus 18, p = .011). The benefit of montelukast occurred both in those using and not using regular inhaled corticosteroids. Boys 2-5 years showed the greatest benefit from montelukast, (0.4% versus 8.8% days with worse asthma symptoms, p<.001), with a lesser effect among 6-9 year olds (2.0% montelukast versus 7.0% placebo, p = .12), and a minimal effect in 10-14 year olds (6.3% montelukast versus 8.2% placebo, p = 0.44). In girls the treatment effect was minimal in 2-5 year olds (5.7% with montelukast, 6.9% with placebo) and in 6-9 year olds (4.5% vs. 4.6%) but strong and significant in 10-14 year olds (4.6 % with montelukast versus17.0% with placebo, p = 0.03). CONCLUSION: Montelukast added to usual treatment substantially reduced the risk of worsening asthma symptoms and unscheduled physician visits during the September asthma epidemic. Treatment effect differences observed between age and sex groups require further investigation in future studies." @default.
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• W2000526237 date "2007-01-01" @default.
• W2000526237 modified "2023-09-25" @default.
• W2000526237 title "Montelukast Added to Usual Therapy during the September Epidemic of Asthma Exacerbations in Children" @default.
• W2000526237 doi "https://doi.org/10.1016/j.jaci.2006.11.032" @default.
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