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- W2000529059 abstract "To analyse the current knowledge concerning anaesthetic malignant hyperthermia.References were obtained from computerized bibliographic research (Medline), recent review articles, the library of the service and personal files.Knowledge to possess, about the diagnosis and treatment of the acute hyperthermia crises and about safe-anaesthesia for malignant hyperthermia susceptible patients, are explained. The pathophysiology chapter give information about the calcium's transport and the defect existing in MH. Molecular genetics of MH find linkage to the region encoding the RyR1. The profile of hyperthermia episodes has changed over time due to the endtidal carbon dioxide-monitoring. Clinical aspects of MH are exposed. The treatment of the acute hyperthermia crises consist mainly to stop all triggering agents instantly and infuse dantrolene sodium. The gold standard for the diagnosis of malignant hyperthermia susceptibility relies on the in vitro contracture test (halothane and caffeine). Associated to genetic studies, it could lead to an non-invasive screening of the MH susceptibility. A protocol for safe-anaesthesia is proposed. Some syndromes with features similar to those of MH should be known (central core disease and exertionnal rhabdomyolysis)." @default.
- W2000529059 created "2016-06-24" @default.
- W2000529059 creator A5006396280 @default.
- W2000529059 creator A5064368271 @default.
- W2000529059 date "2001-12-01" @default.
- W2000529059 modified "2023-09-23" @default.
- W2000529059 title "Hyperthermie maligne : nouveautés diagnostiques et cliniques" @default.
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- W2000529059 doi "https://doi.org/10.1016/s0750-7658(01)00514-7" @default.
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