FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000531527> ?p ?o ?g. }

• W2000531527 endingPage "215" @default.
• W2000531527 startingPage "207" @default.
• W2000531527 abstract "The intracerebroventricular administration of renin substrate or angiotensin II evokes antinociception in rodents, but the brain sites where most of the renin-angiotensin system peptides act are not yet known. This study describes the antinociceptive effects of microinjecting porcine renin substrate tetradecapeptide (RS) or angiotensins I (AI), II (AII) or III (AIII) into different regions of the periaqueductal gray matter (PAG), using the rat tail flick test. All the above peptides were effective following administration into several PAG regions. Their antinociceptive effects were strongly evoked from the caudal ventrolateral and ventral PAG, including the dorsal raphe nucleus. A dose-dependent antinociception following administration into the ventrolateral PAG was demonstrated for all peptides studied. The effect of AII from the ventrolateral PAG was inhibited by the previous local administration of saralasin, a non-selective angiotensin receptor antagonist. Moreover, the peak effects of RS and AI occurred later than those of AII and AIII. The time-course of antinociception suggests that longer-chain peptides are locally processed to biologically active smaller-chain peptides. This study shows for the first time the antinociceptive effect of RS, AI, AII and III in well-defined PAG regions, an effect that is receptor mediated for AII." @default.
• W2000531527 created "2016-06-24" @default.
• W2000531527 creator A5042571757 @default.
• W2000531527 creator A5044671191 @default.
• W2000531527 creator A5052151643 @default.
• W2000531527 date "2003-05-01" @default.
• W2000531527 modified "2023-09-26" @default.
• W2000531527 title "Microinjection of renin–angiotensin system peptides in discrete sites within the rat periaqueductal gray matter elicits antinociception" @default.
• W2000531527 cites W1963618749 @default.
• W2000531527 cites W1982654200 @default.
• W2000531527 cites W1990262681 @default.
• W2000531527 cites W1992841742 @default.
• W2000531527 cites W1997084645 @default.
• W2000531527 cites W2000009623 @default.
• W2000531527 cites W2003979109 @default.
• W2000531527 cites W2023280938 @default.
• W2000531527 cites W2061691710 @default.
• W2000531527 cites W2065242512 @default.
• W2000531527 cites W2070027544 @default.
• W2000531527 cites W2072291822 @default.
• W2000531527 cites W2087454739 @default.
• W2000531527 cites W2123258170 @default.
• W2000531527 cites W2173507839 @default.
• W2000531527 doi "https://doi.org/10.1016/s0006-8993(03)02541-1" @default.
• W2000531527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12711094" @default.
• W2000531527 hasPublicationYear "2003" @default.
• W2000531527 type Work @default.
• W2000531527 sameAs 2000531527 @default.
• W2000531527 citedByCount "32" @default.
• W2000531527 countsByYear W20005315272012 @default.
• W2000531527 countsByYear W20005315272013 @default.
• W2000531527 countsByYear W20005315272014 @default.
• W2000531527 countsByYear W20005315272015 @default.
• W2000531527 countsByYear W20005315272016 @default.
• W2000531527 countsByYear W20005315272017 @default.
• W2000531527 countsByYear W20005315272019 @default.
• W2000531527 countsByYear W20005315272020 @default.
• W2000531527 countsByYear W20005315272021 @default.
• W2000531527 crossrefType "journal-article" @default.
• W2000531527 hasAuthorship W2000531527A5042571757 @default.
• W2000531527 hasAuthorship W2000531527A5044671191 @default.
• W2000531527 hasAuthorship W2000531527A5052151643 @default.
• W2000531527 hasConcept C104849204 @default.
• W2000531527 hasConcept C126322002 @default.
• W2000531527 hasConcept C134018914 @default.
• W2000531527 hasConcept C15490471 @default.
• W2000531527 hasConcept C170493617 @default.
• W2000531527 hasConcept C185592680 @default.
• W2000531527 hasConcept C198710026 @default.
• W2000531527 hasConcept C2776823063 @default.
• W2000531527 hasConcept C2776885963 @default.
• W2000531527 hasConcept C2781069035 @default.
• W2000531527 hasConcept C2908560794 @default.
• W2000531527 hasConcept C2908929049 @default.
• W2000531527 hasConcept C529278444 @default.
• W2000531527 hasConcept C552161191 @default.
• W2000531527 hasConcept C55493867 @default.
• W2000531527 hasConcept C62525196 @default.
• W2000531527 hasConcept C71924100 @default.
• W2000531527 hasConcept C84393581 @default.
• W2000531527 hasConcept C86803240 @default.
• W2000531527 hasConcept C98274493 @default.
• W2000531527 hasConceptScore W2000531527C104849204 @default.
• W2000531527 hasConceptScore W2000531527C126322002 @default.
• W2000531527 hasConceptScore W2000531527C134018914 @default.
• W2000531527 hasConceptScore W2000531527C15490471 @default.
• W2000531527 hasConceptScore W2000531527C170493617 @default.
• W2000531527 hasConceptScore W2000531527C185592680 @default.
• W2000531527 hasConceptScore W2000531527C198710026 @default.
• W2000531527 hasConceptScore W2000531527C2776823063 @default.
• W2000531527 hasConceptScore W2000531527C2776885963 @default.
• W2000531527 hasConceptScore W2000531527C2781069035 @default.
• W2000531527 hasConceptScore W2000531527C2908560794 @default.
• W2000531527 hasConceptScore W2000531527C2908929049 @default.
• W2000531527 hasConceptScore W2000531527C529278444 @default.
• W2000531527 hasConceptScore W2000531527C552161191 @default.
• W2000531527 hasConceptScore W2000531527C55493867 @default.
• W2000531527 hasConceptScore W2000531527C62525196 @default.
• W2000531527 hasConceptScore W2000531527C71924100 @default.
• W2000531527 hasConceptScore W2000531527C84393581 @default.
• W2000531527 hasConceptScore W2000531527C86803240 @default.
• W2000531527 hasConceptScore W2000531527C98274493 @default.
• W2000531527 hasIssue "1-2" @default.
• W2000531527 hasLocation W20005315271 @default.
• W2000531527 hasLocation W20005315272 @default.
• W2000531527 hasOpenAccess W2000531527 @default.
• W2000531527 hasPrimaryLocation W20005315271 @default.
• W2000531527 hasRelatedWork W1891220646 @default.
• W2000531527 hasRelatedWork W1973527030 @default.
• W2000531527 hasRelatedWork W1980330845 @default.
• W2000531527 hasRelatedWork W2038807708 @default.
• W2000531527 hasRelatedWork W2073203285 @default.
• W2000531527 hasRelatedWork W2126797993 @default.
• W2000531527 hasRelatedWork W2172198736 @default.
• W2000531527 hasRelatedWork W2269923018 @default.
• W2000531527 hasRelatedWork W2416079590 @default.
• W2000531527 hasRelatedWork W1996764561 @default.
• W2000531527 hasVolume "972" @default.

• next