FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000532842> ?p ?o ?g. }

• W2000532842 endingPage "e146" @default.
• W2000532842 startingPage "e146" @default.
• W2000532842 abstract "Non-alcoholic fatty liver disease (NAFLD) is an obesity-associated disease, and in obesity adipokines are believed to be involved in the development of NAFLD. However, it is still not clear whether adipokines in the liver and/or adipose tissues can be related to the development of specific characteristics of NAFLD, such as steatosis and inflammation. We aimed to address this question by simultaneously examining the adipokine expression in three tissue types in obese individuals.We enrolled 93 severely obese individuals with NAFLD, varying from simple steatosis to severe non-alcoholic steatohepatitis. Their expression of 48 adipokines in the liver, visceral and subcutaneous adipose tissue (SAT) was correlated to their phenotypic features of NAFLD. We further determined whether the correlations were tissue specific and/or independent of covariates, including age, sex, obesity, insulin resistance and type 2 diabetes (T2D).The expression of adipokines showed a liver- and adipose tissue-specific pattern. We identified that the expression of leptin, angiopoietin 2 (ANGPT2) and chemerin in visceral adipose tissue (VAT) was associated with different NAFLD features, including steatosis, ballooning, portal and lobular inflammation. In addition, the expression of tumor necrosis factor (TNF), plasminogen activator inhibitor type 1 (PAI-1), insulin-like growth factor 1 (somatomedin C) (IGF1) and chemokine (C-X-C motif) ligand 10 (CXCL10) in the liver tissue and the expression of interleukin 1 receptor antagonist (IL1RN) in both the liver and SAT were associated with NAFLD features. The correlations between ANGPT2 and CXCL10, and NAFLD features were dependent on insulin resistance and T2D, but for the other genes the correlation with at least one NAFLD feature remained significant after correcting for the covariates.Our results suggest that in obese individuals, VAT-derived leptin and chemerin, and hepatic expression of TNF, IGF1, IL1RN and PAI-1 are involved in the development of NAFLD features. Further, functional studies are warranted to establish a causal relationship." @default.
• W2000532842 created "2016-06-24" @default.
• W2000532842 creator A5001761419 @default.
• W2000532842 creator A5006921045 @default.
• W2000532842 creator A5011921119 @default.
• W2000532842 creator A5016997548 @default.
• W2000532842 creator A5033865421 @default.
• W2000532842 creator A5035504682 @default.
• W2000532842 creator A5041534953 @default.
• W2000532842 creator A5047999079 @default.
• W2000532842 creator A5062029757 @default.
• W2000532842 creator A5068757919 @default.
• W2000532842 creator A5070771543 @default.
• W2000532842 creator A5074824818 @default.
• W2000532842 creator A5081308630 @default.
• W2000532842 creator A5086707368 @default.
• W2000532842 creator A5088404253 @default.
• W2000532842 date "2015-02-09" @default.
• W2000532842 modified "2023-10-18" @default.
• W2000532842 title "Determining the association between adipokine expression in multiple tissues and phenotypic features of non-alcoholic fatty liver disease in obesity" @default.
• W2000532842 cites W1608726413 @default.
• W2000532842 cites W1631449371 @default.
• W2000532842 cites W1921378646 @default.
• W2000532842 cites W1923608016 @default.
• W2000532842 cites W1940950287 @default.
• W2000532842 cites W1967901622 @default.
• W2000532842 cites W1967972402 @default.
• W2000532842 cites W1974005261 @default.
• W2000532842 cites W1975805815 @default.
• W2000532842 cites W1979605665 @default.
• W2000532842 cites W1983417944 @default.
• W2000532842 cites W1985222413 @default.
• W2000532842 cites W1992909012 @default.
• W2000532842 cites W1998934232 @default.
• W2000532842 cites W1998972875 @default.
• W2000532842 cites W2001495518 @default.
• W2000532842 cites W2001837599 @default.
• W2000532842 cites W2002382034 @default.
• W2000532842 cites W2018581697 @default.
• W2000532842 cites W2018757636 @default.
• W2000532842 cites W2025599322 @default.
• W2000532842 cites W2042555983 @default.
• W2000532842 cites W2047499703 @default.
• W2000532842 cites W2049691915 @default.
• W2000532842 cites W2054208989 @default.
• W2000532842 cites W2055317878 @default.
• W2000532842 cites W2055355179 @default.
• W2000532842 cites W2057110290 @default.
• W2000532842 cites W2059370065 @default.
• W2000532842 cites W2065612971 @default.
• W2000532842 cites W2065974239 @default.
• W2000532842 cites W2067740038 @default.
• W2000532842 cites W2087265885 @default.
• W2000532842 cites W2096301780 @default.
• W2000532842 cites W2098895307 @default.
• W2000532842 cites W2100168771 @default.
• W2000532842 cites W2100784798 @default.
• W2000532842 cites W2134626804 @default.
• W2000532842 cites W2136795008 @default.
• W2000532842 cites W2142153422 @default.
• W2000532842 cites W2145412044 @default.
• W2000532842 cites W2155853498 @default.
• W2000532842 cites W2164118055 @default.
• W2000532842 cites W2164255675 @default.
• W2000532842 cites W2165120659 @default.
• W2000532842 cites W2165275387 @default.
• W2000532842 cites W2168280979 @default.
• W2000532842 doi "https://doi.org/10.1038/nutd.2014.43" @default.
• W2000532842 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4338415" @default.
• W2000532842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25664838" @default.
• W2000532842 hasPublicationYear "2015" @default.
• W2000532842 type Work @default.
• W2000532842 sameAs 2000532842 @default.
• W2000532842 citedByCount "42" @default.
• W2000532842 countsByYear W20005328422015 @default.
• W2000532842 countsByYear W20005328422016 @default.
• W2000532842 countsByYear W20005328422017 @default.
• W2000532842 countsByYear W20005328422018 @default.
• W2000532842 countsByYear W20005328422019 @default.
• W2000532842 countsByYear W20005328422020 @default.
• W2000532842 countsByYear W20005328422021 @default.
• W2000532842 countsByYear W20005328422022 @default.
• W2000532842 countsByYear W20005328422023 @default.
• W2000532842 crossrefType "journal-article" @default.
• W2000532842 hasAuthorship W2000532842A5001761419 @default.
• W2000532842 hasAuthorship W2000532842A5006921045 @default.
• W2000532842 hasAuthorship W2000532842A5011921119 @default.
• W2000532842 hasAuthorship W2000532842A5016997548 @default.
• W2000532842 hasAuthorship W2000532842A5033865421 @default.
• W2000532842 hasAuthorship W2000532842A5035504682 @default.
• W2000532842 hasAuthorship W2000532842A5041534953 @default.
• W2000532842 hasAuthorship W2000532842A5047999079 @default.
• W2000532842 hasAuthorship W2000532842A5062029757 @default.
• W2000532842 hasAuthorship W2000532842A5068757919 @default.
• W2000532842 hasAuthorship W2000532842A5070771543 @default.
• W2000532842 hasAuthorship W2000532842A5074824818 @default.
• W2000532842 hasAuthorship W2000532842A5081308630 @default.
• W2000532842 hasAuthorship W2000532842A5086707368 @default.

• next