FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000534176> ?p ?o ?g. }

• W2000534176 endingPage "4991" @default.
• W2000534176 startingPage "4991" @default.
• W2000534176 abstract "Enhancement of oral bioavailability of cyclosporine A: comparison of various nanoscale drug-delivery systems Kai Wang,1–3 Jianping Qi,1 Tengfei Weng,1,2 Zhiqiang Tian,1 Yi Lu,1 Kaili Hu,4 Zongning Yin,2 Wei Wu1 1School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery of Ministry of Education, Shanghai, People’s Republic of China; 2West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 3Tropical Crops Genetic Resources Institute, Hainan Provincial Engineering Research Center for Blumea Balsamifera, Chinese Academy of Tropical Agricultural Sciences, Danzhou, Hainan, People’s Republic of China; 4Murad Research Center for Modernized Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of ChinaAbstract: A variety of nanoscale delivery systems have been shown to enhance the oral absorption of poorly water-soluble and poorly permeable drugs. However, the performance of these systems has seldom been evaluated simultaneously. The aim of this study was to compare the bioavailability enhancement effect of lipid-based nanocarriers with poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) to highlight the importance of the lipid composition, with cyclosporine A (CyA) as a model drug. CyA-loaded PLGA NPs, nanostructured lipid carriers (NLCs), and self-microemulsifying drug-delivery systems (SMEDDS) were prepared. The particle size of PLGA NPs (182.2±12.8 nm) was larger than that of NLCs (89.7±9.0 nm) and SMEDDS (26.9±1.9 nm). All vehicles are charged negatively. The entrapment efficiency of PLGA NPs and NLCs was 87.6%±1.6% and 80.3%±0.6%, respectively. In vitro release tests indicated that the cumulative release of CyA was lower than 4% from all vehicles, including Sandimmun Neoral®, according to the dialysis method. Both NLCs and SMEDDS showed high relative oral bioavailability, 111.8% and 73.6%, respectively, after oral gavage administration to beagle dogs, which was not statistically different from commercial Sandimmun Neoral®. However, PLGA NPs failed to achieve efficient absorption, with relative bioavailability of about 22.7%. It is concluded that lipid-based nanoscale drug-delivery systems are superior to polymeric NPs in enhancing oral bioavailability of poorly water-soluble and poorly permeable drugs. Keywords: cyclosporine A, PLGA nanoparticle, nanostructured lipid carrier, self-microemulsifying drug-delivery systems, bioavailability" @default.
• W2000534176 created "2016-06-24" @default.
• W2000534176 creator A5009488278 @default.
• W2000534176 creator A5022429448 @default.
• W2000534176 creator A5023925767 @default.
• W2000534176 creator A5041357914 @default.
• W2000534176 creator A5045895961 @default.
• W2000534176 creator A5051178495 @default.
• W2000534176 creator A5073531557 @default.
• W2000534176 creator A5078874344 @default.
• W2000534176 date "2014-10-01" @default.
• W2000534176 modified "2023-10-17" @default.
• W2000534176 title "Enhancement of oral bioavailability of cyclosporine A: comparison of various nanoscale&nbsp;drug-delivery systems" @default.
• W2000534176 cites W105785269 @default.
• W2000534176 cites W1498305210 @default.
• W2000534176 cites W176348932 @default.
• W2000534176 cites W1965779517 @default.
• W2000534176 cites W1980063725 @default.
• W2000534176 cites W1989602366 @default.
• W2000534176 cites W1989945146 @default.
• W2000534176 cites W1990648838 @default.
• W2000534176 cites W1999312756 @default.
• W2000534176 cites W2006896008 @default.
• W2000534176 cites W2006962245 @default.
• W2000534176 cites W2007788734 @default.
• W2000534176 cites W2010908849 @default.
• W2000534176 cites W2012095032 @default.
• W2000534176 cites W2019124020 @default.
• W2000534176 cites W2024247790 @default.
• W2000534176 cites W2028309493 @default.
• W2000534176 cites W2030374993 @default.
• W2000534176 cites W2030883001 @default.
• W2000534176 cites W2033305262 @default.
• W2000534176 cites W2033939437 @default.
• W2000534176 cites W2034555772 @default.
• W2000534176 cites W2038795968 @default.
• W2000534176 cites W2041016731 @default.
• W2000534176 cites W2044779642 @default.
• W2000534176 cites W2051959623 @default.
• W2000534176 cites W2055659687 @default.
• W2000534176 cites W2059134227 @default.
• W2000534176 cites W2070228598 @default.
• W2000534176 cites W2072506725 @default.
• W2000534176 cites W2072768012 @default.
• W2000534176 cites W2077510533 @default.
• W2000534176 cites W2078481291 @default.
• W2000534176 cites W2082444123 @default.
• W2000534176 cites W2087148652 @default.
• W2000534176 cites W2087627688 @default.
• W2000534176 cites W2109391543 @default.
• W2000534176 cites W2111598142 @default.
• W2000534176 cites W2132081026 @default.
• W2000534176 cites W2135894523 @default.
• W2000534176 cites W2140067957 @default.
• W2000534176 cites W2148628183 @default.
• W2000534176 cites W2156829937 @default.
• W2000534176 cites W2161920005 @default.
• W2000534176 cites W2167878693 @default.
• W2000534176 cites W2331793612 @default.
• W2000534176 doi "https://doi.org/10.2147/ijn.s72560" @default.
• W2000534176 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4218918" @default.
• W2000534176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25378925" @default.
• W2000534176 hasPublicationYear "2014" @default.
• W2000534176 type Work @default.
• W2000534176 sameAs 2000534176 @default.
• W2000534176 citedByCount "14" @default.
• W2000534176 countsByYear W20005341762015 @default.
• W2000534176 countsByYear W20005341762016 @default.
• W2000534176 countsByYear W20005341762018 @default.
• W2000534176 countsByYear W20005341762019 @default.
• W2000534176 countsByYear W20005341762020 @default.
• W2000534176 countsByYear W20005341762021 @default.
• W2000534176 countsByYear W20005341762022 @default.
• W2000534176 crossrefType "journal-article" @default.
• W2000534176 hasAuthorship W2000534176A5009488278 @default.
• W2000534176 hasAuthorship W2000534176A5022429448 @default.
• W2000534176 hasAuthorship W2000534176A5023925767 @default.
• W2000534176 hasAuthorship W2000534176A5041357914 @default.
• W2000534176 hasAuthorship W2000534176A5045895961 @default.
• W2000534176 hasAuthorship W2000534176A5051178495 @default.
• W2000534176 hasAuthorship W2000534176A5073531557 @default.
• W2000534176 hasAuthorship W2000534176A5078874344 @default.
• W2000534176 hasBestOaLocation W20005341761 @default.
• W2000534176 hasConcept C171250308 @default.
• W2000534176 hasConcept C178855305 @default.
• W2000534176 hasConcept C181389837 @default.
• W2000534176 hasConcept C18150654 @default.
• W2000534176 hasConcept C192562407 @default.
• W2000534176 hasConcept C2779820397 @default.
• W2000534176 hasConcept C556039675 @default.
• W2000534176 hasConcept C71924100 @default.
• W2000534176 hasConcept C98274493 @default.
• W2000534176 hasConceptScore W2000534176C171250308 @default.
• W2000534176 hasConceptScore W2000534176C178855305 @default.
• W2000534176 hasConceptScore W2000534176C181389837 @default.
• W2000534176 hasConceptScore W2000534176C18150654 @default.
• W2000534176 hasConceptScore W2000534176C192562407 @default.
• W2000534176 hasConceptScore W2000534176C2779820397 @default.

• next