Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000534340> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2000534340 abstract "Up to two-thirds of patients with systemic lupus erythematosus develop renal disease at some stage of their disease. Diffuse proliferative forms (type IV) have the worst prognosis due to the risk of progression to chronic renal insufficiency (CRI). In these patients, aggressive immunosuppressive therapy is required to induce clinical remission, followed by maintenance therapy to preserve renal function.The first clinical trials demonstrated the need for maintenance therapy in these severe forms; regimens consisting of intravenous cyclophosphamide (CYF) administered quarterly after the induction phase reduced the risk of progression to CRI. Subsequently, because of the long-term risk posed by extended courses of CYF, the use of mycophenolate mofetil (MMF) and azathioprine for maintenance therapy was investigated. In patients with proliferative lupus nephritis, AZA and MMF are good options for maintenance therapy, but are not superior to CYF pulses. Current information on maintenance therapy in proliferative lupus nephritis is based on a small number of studies with major methodological limitations.Consequently, there is clearly a need for further well-designed studies of the most recent therapeutic options. Equally, control of cardiovascular risk factors and the use of additional therapies that avoid the adverse effects of these immunosuppressive agents are required to improve the management of patients with type IV lupus nephritis." @default.
- W2000534340 created "2016-06-24" @default.
- W2000534340 creator A5044679511 @default.
- W2000534340 creator A5052498714 @default.
- W2000534340 date "2009-03-01" @default.
- W2000534340 modified "2023-09-28" @default.
- W2000534340 title "¿Cuál es el mejor tratamiento de mantenimiento de la nefritis lúpica tipo IV?" @default.
- W2000534340 cites W1491038651 @default.
- W2000534340 cites W1890638053 @default.
- W2000534340 cites W1971058219 @default.
- W2000534340 cites W1974536493 @default.
- W2000534340 cites W1987922228 @default.
- W2000534340 cites W1997001269 @default.
- W2000534340 cites W2005953407 @default.
- W2000534340 cites W2010912810 @default.
- W2000534340 cites W2019229100 @default.
- W2000534340 cites W2023341006 @default.
- W2000534340 cites W2024442997 @default.
- W2000534340 cites W2036335844 @default.
- W2000534340 cites W2048350130 @default.
- W2000534340 cites W2055581363 @default.
- W2000534340 cites W2068492012 @default.
- W2000534340 cites W2077293946 @default.
- W2000534340 cites W2082186952 @default.
- W2000534340 cites W2087785715 @default.
- W2000534340 cites W2094074845 @default.
- W2000534340 cites W2099338332 @default.
- W2000534340 cites W2121956201 @default.
- W2000534340 cites W2122338150 @default.
- W2000534340 cites W2128459490 @default.
- W2000534340 cites W2135212798 @default.
- W2000534340 cites W2139053246 @default.
- W2000534340 cites W2149882694 @default.
- W2000534340 cites W2325870812 @default.
- W2000534340 cites W2336696641 @default.
- W2000534340 cites W2339857727 @default.
- W2000534340 cites W2414784657 @default.
- W2000534340 cites W2842267605 @default.
- W2000534340 cites W3156996711 @default.
- W2000534340 doi "https://doi.org/10.1016/s1577-3566(09)70937-6" @default.
- W2000534340 hasPublicationYear "2009" @default.
- W2000534340 type Work @default.
- W2000534340 sameAs 2000534340 @default.
- W2000534340 citedByCount "0" @default.
- W2000534340 crossrefType "journal-article" @default.
- W2000534340 hasAuthorship W2000534340A5044679511 @default.
- W2000534340 hasAuthorship W2000534340A5052498714 @default.
- W2000534340 hasConcept C126322002 @default.
- W2000534340 hasConcept C177713679 @default.
- W2000534340 hasConcept C197934379 @default.
- W2000534340 hasConcept C2776694085 @default.
- W2000534340 hasConcept C2776755627 @default.
- W2000534340 hasConcept C2776760755 @default.
- W2000534340 hasConcept C2777058396 @default.
- W2000534340 hasConcept C2778283404 @default.
- W2000534340 hasConcept C2779134260 @default.
- W2000534340 hasConcept C2779912601 @default.
- W2000534340 hasConcept C71924100 @default.
- W2000534340 hasConceptScore W2000534340C126322002 @default.
- W2000534340 hasConceptScore W2000534340C177713679 @default.
- W2000534340 hasConceptScore W2000534340C197934379 @default.
- W2000534340 hasConceptScore W2000534340C2776694085 @default.
- W2000534340 hasConceptScore W2000534340C2776755627 @default.
- W2000534340 hasConceptScore W2000534340C2776760755 @default.
- W2000534340 hasConceptScore W2000534340C2777058396 @default.
- W2000534340 hasConceptScore W2000534340C2778283404 @default.
- W2000534340 hasConceptScore W2000534340C2779134260 @default.
- W2000534340 hasConceptScore W2000534340C2779912601 @default.
- W2000534340 hasConceptScore W2000534340C71924100 @default.
- W2000534340 hasLocation W20005343401 @default.
- W2000534340 hasOpenAccess W2000534340 @default.
- W2000534340 hasPrimaryLocation W20005343401 @default.
- W2000534340 isParatext "false" @default.
- W2000534340 isRetracted "false" @default.
- W2000534340 magId "2000534340" @default.
- W2000534340 workType "article" @default.