FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000534903> ?p ?o ?g. }

• W2000534903 endingPage "1469" @default.
• W2000534903 startingPage "1463" @default.
• W2000534903 abstract "Estrogens are effective antioxidants in diverse biological systems. Despite their antioxidant activities, it is not known yet whether estrogens prevent or alleviate liver toxicity induced by oxidative stress. In the present work, we studied this possibility by examining in vitro the protective potential of different estrogen compounds (17beta-estradiol, 2-hydroxyestradiol, and diethylstilbestrol) against tert-butyl hydroperoxide-induced hepatocyte damage. Various parameters such as cell viability, lipid peroxidation, adenine nucleotide content, and thiol status were measured as an index of cytotoxicity. The protective effects of estrogens were compared to those of the iron chelator deferoxamine. The molecules tested prevented oxidant-induced cell death differently, showing variable degrees of protection. Deferoxamine was the most potent agent, followed by diethylstilbestrol and 2-hydroxyestradiol, 17beta-estradiol being the least efficient. The inhibitory effects on lipid and thiol oxidations paralleled the effects on cell viability. The molecules also reduced the oxidant-induced ATP depletion, except for 17beta-estradiol which had no effect on the decreased ATP levels. Our results suggest that the mechanisms of the preventive actions of estrogens may be related not only to their antioxidant activity against free radicals, but also and to a lesser extent to the maintenance of the normal redox status of the cell, which partially recovers the intracellular GSH levels." @default.
• W2000534903 created "2016-06-24" @default.
• W2000534903 creator A5016527995 @default.
• W2000534903 creator A5025719092 @default.
• W2000534903 creator A5057061230 @default.
• W2000534903 creator A5082503438 @default.
• W2000534903 date "1998-12-01" @default.
• W2000534903 modified "2023-10-02" @default.
• W2000534903 title "Cytoprotective actions of estrogens against tert-butyl hydroperoxide-induced toxicity in hepatocytes" @default.
• W2000534903 cites W1485543100 @default.
• W2000534903 cites W1526965567 @default.
• W2000534903 cites W1774165831 @default.
• W2000534903 cites W1958748370 @default.
• W2000534903 cites W1966351239 @default.
• W2000534903 cites W1971642052 @default.
• W2000534903 cites W1971804221 @default.
• W2000534903 cites W1972634206 @default.
• W2000534903 cites W1986193822 @default.
• W2000534903 cites W2006582421 @default.
• W2000534903 cites W2006608921 @default.
• W2000534903 cites W2008885463 @default.
• W2000534903 cites W2018214249 @default.
• W2000534903 cites W2026454478 @default.
• W2000534903 cites W2027858926 @default.
• W2000534903 cites W2028000670 @default.
• W2000534903 cites W2029335737 @default.
• W2000534903 cites W2033243295 @default.
• W2000534903 cites W2037091305 @default.
• W2000534903 cites W2042520653 @default.
• W2000534903 cites W2065997722 @default.
• W2000534903 cites W2071852450 @default.
• W2000534903 cites W2072655765 @default.
• W2000534903 cites W2072926655 @default.
• W2000534903 cites W2081423279 @default.
• W2000534903 cites W2082648762 @default.
• W2000534903 cites W2102131116 @default.
• W2000534903 cites W2116939771 @default.
• W2000534903 cites W2132298206 @default.
• W2000534903 cites W2164325285 @default.
• W2000534903 cites W2327141478 @default.
• W2000534903 doi "https://doi.org/10.1016/s0006-2952(98)00248-2" @default.
• W2000534903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9827578" @default.
• W2000534903 hasPublicationYear "1998" @default.
• W2000534903 type Work @default.
• W2000534903 sameAs 2000534903 @default.
• W2000534903 citedByCount "43" @default.
• W2000534903 countsByYear W20005349032012 @default.
• W2000534903 countsByYear W20005349032013 @default.
• W2000534903 countsByYear W20005349032015 @default.
• W2000534903 countsByYear W20005349032019 @default.
• W2000534903 crossrefType "journal-article" @default.
• W2000534903 hasAuthorship W2000534903A5016527995 @default.
• W2000534903 hasAuthorship W2000534903A5025719092 @default.
• W2000534903 hasAuthorship W2000534903A5057061230 @default.
• W2000534903 hasAuthorship W2000534903A5082503438 @default.
• W2000534903 hasConcept C134018914 @default.
• W2000534903 hasConcept C1491633281 @default.
• W2000534903 hasConcept C178790620 @default.
• W2000534903 hasConcept C181199279 @default.
• W2000534903 hasConcept C185592680 @default.
• W2000534903 hasConcept C202751555 @default.
• W2000534903 hasConcept C2776151105 @default.
• W2000534903 hasConcept C2776200302 @default.
• W2000534903 hasConcept C2776672577 @default.
• W2000534903 hasConcept C2777164284 @default.
• W2000534903 hasConcept C2778004101 @default.
• W2000534903 hasConcept C2780829032 @default.
• W2000534903 hasConcept C2781397067 @default.
• W2000534903 hasConcept C29730261 @default.
• W2000534903 hasConcept C53227056 @default.
• W2000534903 hasConcept C538909803 @default.
• W2000534903 hasConcept C55493867 @default.
• W2000534903 hasConcept C71315377 @default.
• W2000534903 hasConcept C86803240 @default.
• W2000534903 hasConcept C98274493 @default.
• W2000534903 hasConceptScore W2000534903C134018914 @default.
• W2000534903 hasConceptScore W2000534903C1491633281 @default.
• W2000534903 hasConceptScore W2000534903C178790620 @default.
• W2000534903 hasConceptScore W2000534903C181199279 @default.
• W2000534903 hasConceptScore W2000534903C185592680 @default.
• W2000534903 hasConceptScore W2000534903C202751555 @default.
• W2000534903 hasConceptScore W2000534903C2776151105 @default.
• W2000534903 hasConceptScore W2000534903C2776200302 @default.
• W2000534903 hasConceptScore W2000534903C2776672577 @default.
• W2000534903 hasConceptScore W2000534903C2777164284 @default.
• W2000534903 hasConceptScore W2000534903C2778004101 @default.
• W2000534903 hasConceptScore W2000534903C2780829032 @default.
• W2000534903 hasConceptScore W2000534903C2781397067 @default.
• W2000534903 hasConceptScore W2000534903C29730261 @default.
• W2000534903 hasConceptScore W2000534903C53227056 @default.
• W2000534903 hasConceptScore W2000534903C538909803 @default.
• W2000534903 hasConceptScore W2000534903C55493867 @default.
• W2000534903 hasConceptScore W2000534903C71315377 @default.
• W2000534903 hasConceptScore W2000534903C86803240 @default.
• W2000534903 hasConceptScore W2000534903C98274493 @default.
• W2000534903 hasIssue "11" @default.
• W2000534903 hasLocation W20005349031 @default.
• W2000534903 hasLocation W20005349032 @default.

• next