Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000535244> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2000535244 endingPage "8153" @default.
- W2000535244 startingPage "8149" @default.
- W2000535244 abstract "The three-dimensional structure of human beta 1 beta 1 alcohol dehydrogenase (ADH; EC 1.1.1.1) complexed with NAD+ has been determined by x-ray crystallography to 3.0-A resolution. The amino acids directly involved in coenzyme binding are conserved between horse EE and human beta 1 beta 1 alcohol dehydrogenase in all but one case [serine (horse) vs. threonine (human) at position 48]. As a result, the coenzyme molecule is bound in a similar manner in the two enzymes. However, the strength of the interactions in the vicinity of the pyrophosphate bridge of NAD+ appears to be enhanced in the human enzyme. Side-chain movements of Arg-47 and Asp-50 and a shift in the position of the helix comprising residues 202-212 may explain both the decreased Vmax and the decreased rate of NADH dissociation observed in the human enzyme vs. the horse enzyme. It appears that these catalytic differences are not due to substitutions of any amino acids directly involved in coenzyme binding but are the result of structural rearrangements resulting from multiple sequence differences between the two enzymes." @default.
- W2000535244 created "2016-06-24" @default.
- W2000535244 creator A5014286175 @default.
- W2000535244 creator A5022659010 @default.
- W2000535244 creator A5031403355 @default.
- W2000535244 creator A5061958333 @default.
- W2000535244 date "1991-09-15" @default.
- W2000535244 modified "2023-10-02" @default.
- W2000535244 title "Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions." @default.
- W2000535244 cites W1544860800 @default.
- W2000535244 cites W1577645177 @default.
- W2000535244 cites W1585301053 @default.
- W2000535244 cites W1608052268 @default.
- W2000535244 cites W1970168533 @default.
- W2000535244 cites W1989443275 @default.
- W2000535244 cites W1993390869 @default.
- W2000535244 cites W2010870281 @default.
- W2000535244 cites W2017774801 @default.
- W2000535244 cites W2021188450 @default.
- W2000535244 cites W2022719316 @default.
- W2000535244 cites W2052928475 @default.
- W2000535244 cites W2056770911 @default.
- W2000535244 cites W2078763795 @default.
- W2000535244 cites W2081359387 @default.
- W2000535244 cites W2412479124 @default.
- W2000535244 doi "https://doi.org/10.1073/pnas.88.18.8149" @default.
- W2000535244 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/52464" @default.
- W2000535244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1896463" @default.
- W2000535244 hasPublicationYear "1991" @default.
- W2000535244 type Work @default.
- W2000535244 sameAs 2000535244 @default.
- W2000535244 citedByCount "82" @default.
- W2000535244 countsByYear W20005352442012 @default.
- W2000535244 countsByYear W20005352442017 @default.
- W2000535244 countsByYear W20005352442021 @default.
- W2000535244 countsByYear W20005352442023 @default.
- W2000535244 crossrefType "journal-article" @default.
- W2000535244 hasAuthorship W2000535244A5014286175 @default.
- W2000535244 hasAuthorship W2000535244A5022659010 @default.
- W2000535244 hasAuthorship W2000535244A5031403355 @default.
- W2000535244 hasAuthorship W2000535244A5061958333 @default.
- W2000535244 hasBestOaLocation W20005352441 @default.
- W2000535244 hasConcept C181199279 @default.
- W2000535244 hasConcept C185592680 @default.
- W2000535244 hasConcept C197957613 @default.
- W2000535244 hasConcept C2775880066 @default.
- W2000535244 hasConcept C2776317432 @default.
- W2000535244 hasConcept C2776414213 @default.
- W2000535244 hasConcept C2777344606 @default.
- W2000535244 hasConcept C2779268744 @default.
- W2000535244 hasConcept C41183919 @default.
- W2000535244 hasConcept C515207424 @default.
- W2000535244 hasConcept C55493867 @default.
- W2000535244 hasConcept C71240020 @default.
- W2000535244 hasConcept C75520062 @default.
- W2000535244 hasConcept C86803240 @default.
- W2000535244 hasConceptScore W2000535244C181199279 @default.
- W2000535244 hasConceptScore W2000535244C185592680 @default.
- W2000535244 hasConceptScore W2000535244C197957613 @default.
- W2000535244 hasConceptScore W2000535244C2775880066 @default.
- W2000535244 hasConceptScore W2000535244C2776317432 @default.
- W2000535244 hasConceptScore W2000535244C2776414213 @default.
- W2000535244 hasConceptScore W2000535244C2777344606 @default.
- W2000535244 hasConceptScore W2000535244C2779268744 @default.
- W2000535244 hasConceptScore W2000535244C41183919 @default.
- W2000535244 hasConceptScore W2000535244C515207424 @default.
- W2000535244 hasConceptScore W2000535244C55493867 @default.
- W2000535244 hasConceptScore W2000535244C71240020 @default.
- W2000535244 hasConceptScore W2000535244C75520062 @default.
- W2000535244 hasConceptScore W2000535244C86803240 @default.
- W2000535244 hasIssue "18" @default.
- W2000535244 hasLocation W20005352441 @default.
- W2000535244 hasLocation W20005352442 @default.
- W2000535244 hasLocation W20005352443 @default.
- W2000535244 hasLocation W20005352444 @default.
- W2000535244 hasOpenAccess W2000535244 @default.
- W2000535244 hasPrimaryLocation W20005352441 @default.
- W2000535244 hasRelatedWork W1953994264 @default.
- W2000535244 hasRelatedWork W1967644006 @default.
- W2000535244 hasRelatedWork W1971241791 @default.
- W2000535244 hasRelatedWork W2008476781 @default.
- W2000535244 hasRelatedWork W2044551883 @default.
- W2000535244 hasRelatedWork W2085330586 @default.
- W2000535244 hasRelatedWork W2161994171 @default.
- W2000535244 hasRelatedWork W4207073596 @default.
- W2000535244 hasRelatedWork W4229372104 @default.
- W2000535244 hasRelatedWork W4233933829 @default.
- W2000535244 hasVolume "88" @default.
- W2000535244 isParatext "false" @default.
- W2000535244 isRetracted "false" @default.
- W2000535244 magId "2000535244" @default.
- W2000535244 workType "article" @default.