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- W2000535484 abstract "A DNA methyltransferase was partially purified from bovine thymus heavy cells. The enzyme has Mr 130 000, and introduces methyl groups from S-adenosylmethionine into the 5 position of cytosines in DNA. Sequence specificity analysis revealed that about 60% of the total methylation occurred in the 5'd(C-G)3' doublet. Single-stranded and hemi-methylated DNAs were methylated at an elevated rate by the enzyme. The kinetic analysis showed that the reaction obeys a random sequential mechanism. These results suggest that the enzyme serves primarily as a maintenance DNA methyltransferase." @default.
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- W2000535484 date "1983-09-01" @default.
- W2000535484 modified "2023-10-14" @default.
- W2000535484 title "Characterization of DNA methyltransferase from bovine thymus cells" @default.
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- W2000535484 doi "https://doi.org/10.1111/j.1432-1033.1983.tb07635.x" @default.
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