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- W2000535560 abstract "PURPOSE: To measure the influence of vitamin C (N = 15) compared to placebo (N = 13) supplementation on oxidative and immune changes in runners competing in an ultramarathon race. METHODS: During the 7-d period prior to the race, subjects ingested in randomized, double-blind fashion three 500-mg tablets of vitamin C or placebo each day. On race day, blood samples were collected 1 h pre-race, after 32 km of running, and then again immediately post-race. During the race, runners received 1 l/h carbohydrate beverages with (150 mg/l) or without vitamin C in a double-blinded fashion. RESULTS: Subjects in both groups maintained an intensity of approximately 75% HRmax throughout the ultramaraton race, and ran a mean of 69 km (range 48 to 80 km) in 9.8 hours (range 5 to 12 hours). Plasma ascorbic acid was markedly higher in the vitamin C compared to placebo group pre-race, and rose more strongly in the vitamin C group during the race (post-race, 3.21 ± 0.29 and 1.28 ± 0.12 μg/100μl, respectively, P < 0.001). No significant group or interaction effects were measured for lipid hydroperoxide and F2-isoprostance, but both oxidative measures rose significantly during the ultramarathon race. No significant group or interaction effects were measured for immune cell counts, plasma IL-6, IL-10, IL-1ra, or IL-8 concentrations, or mitogen-stimulated lymphocyte profiferation and IL-2 and IFN-gamma production. No significant correlations were found between post-race plasma vitamin C, oxidative, and immune measures except for a positive correlation between F2-isoprostane and plasma IL-10 (r = 0.42, P = 0.026). CONCLUSION: These data indicate that vitamin C supplementation in carbohydrate-fed runners does not serve as a countermeasure to oxidative and immune changes during or following a competitive ultramarathon race. Supported by the Gatorade Sports Science Institute." @default.
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- W2000535560 date "2002-05-01" @default.
- W2000535560 modified "2023-09-27" @default.
- W2000535560 title "INFLUENCE OF VITAMIN C SUPPLEMENTATION ON OXIDATIVE AND IMMUNE CHANGES FOLLOWING AN ULTRAMARATHON" @default.
- W2000535560 doi "https://doi.org/10.1097/00005768-200205001-00514" @default.
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