FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000536375> ?p ?o ?g. }

• W2000536375 endingPage "2319" @default.
• W2000536375 startingPage "2311" @default.
• W2000536375 abstract "P-glycoprotein (P-gp) is an ATP-dependent multidrug resistance efflux transporter that plays an important role in anticancer drug resistance and in pharmacokinetics of medicines. Despite a large number of structurally and functionally diverse compounds, also flavonoids and chalcones have been reported as inhibitors of P-gp. The latter share some similarity with the well studied class of propafenones, but do not contain a basic nitrogen atom. Furthermore, due to their rigidity, they are suitable candidates for 3D-QSAR studies. In this study, a set of 22 new chalcone derivatives were synthesized and evaluated in a daunomycin efflux inhibition assay using the CCRF.CEM.VCR1000 cell line. The compound 10 showed the highest activity (IC50=42nM), which is one order of magnitude higher than the activity for an equilipohillic propafenone analogue. 2D- and 3D-QSAR studies indicate the importance of H-bond acceptors, methoxy groups, hydrophobic groups as well as the number of rotatable bonds as pharmacophoric features influencing P-gp inhibitory activity." @default.
• W2000536375 created "2016-06-24" @default.
• W2000536375 creator A5025683351 @default.
• W2000536375 creator A5047990830 @default.
• W2000536375 creator A5053418144 @default.
• W2000536375 creator A5056834055 @default.
• W2000536375 creator A5064366606 @default.
• W2000536375 creator A5077706191 @default.
• W2000536375 date "2014-04-01" @default.
• W2000536375 modified "2023-10-16" @default.
• W2000536375 title "Synthesis, biological evaluation and 3D-QSAR studies of new chalcone derivatives as inhibitors of human P-glycoprotein" @default.
• W2000536375 cites W1964118830 @default.
• W2000536375 cites W1965984570 @default.
• W2000536375 cites W1967517956 @default.
• W2000536375 cites W1972882617 @default.
• W2000536375 cites W1983389988 @default.
• W2000536375 cites W1987792429 @default.
• W2000536375 cites W1992630127 @default.
• W2000536375 cites W2008935282 @default.
• W2000536375 cites W2009633685 @default.
• W2000536375 cites W2012334764 @default.
• W2000536375 cites W2014123957 @default.
• W2000536375 cites W2021406861 @default.
• W2000536375 cites W2030864608 @default.
• W2000536375 cites W2040651998 @default.
• W2000536375 cites W2045973642 @default.
• W2000536375 cites W2054167651 @default.
• W2000536375 cites W2056593372 @default.
• W2000536375 cites W2058052390 @default.
• W2000536375 cites W2060555150 @default.
• W2000536375 cites W2076522413 @default.
• W2000536375 cites W2077736303 @default.
• W2000536375 cites W2079472356 @default.
• W2000536375 cites W2081810144 @default.
• W2000536375 cites W2084785617 @default.
• W2000536375 cites W2114577232 @default.
• W2000536375 cites W2133228174 @default.
• W2000536375 cites W2135823421 @default.
• W2000536375 cites W2151325092 @default.
• W2000536375 cites W2157393167 @default.
• W2000536375 cites W2166082449 @default.
• W2000536375 cites W2166628294 @default.
• W2000536375 cites W2328304582 @default.
• W2000536375 cites W2951960697 @default.
• W2000536375 cites W2953219651 @default.
• W2000536375 doi "https://doi.org/10.1016/j.bmc.2014.02.005" @default.
• W2000536375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24613626" @default.
• W2000536375 hasPublicationYear "2014" @default.
• W2000536375 type Work @default.
• W2000536375 sameAs 2000536375 @default.
• W2000536375 citedByCount "34" @default.
• W2000536375 countsByYear W20005363752014 @default.
• W2000536375 countsByYear W20005363752015 @default.
• W2000536375 countsByYear W20005363752016 @default.
• W2000536375 countsByYear W20005363752017 @default.
• W2000536375 countsByYear W20005363752018 @default.
• W2000536375 countsByYear W20005363752019 @default.
• W2000536375 countsByYear W20005363752020 @default.
• W2000536375 countsByYear W20005363752021 @default.
• W2000536375 countsByYear W20005363752022 @default.
• W2000536375 countsByYear W20005363752023 @default.
• W2000536375 crossrefType "journal-article" @default.
• W2000536375 hasAuthorship W2000536375A5025683351 @default.
• W2000536375 hasAuthorship W2000536375A5047990830 @default.
• W2000536375 hasAuthorship W2000536375A5053418144 @default.
• W2000536375 hasAuthorship W2000536375A5056834055 @default.
• W2000536375 hasAuthorship W2000536375A5064366606 @default.
• W2000536375 hasAuthorship W2000536375A5077706191 @default.
• W2000536375 hasConcept C133936738 @default.
• W2000536375 hasConcept C164126121 @default.
• W2000536375 hasConcept C185592680 @default.
• W2000536375 hasConcept C200082930 @default.
• W2000536375 hasConcept C202751555 @default.
• W2000536375 hasConcept C2777752497 @default.
• W2000536375 hasConcept C2778707650 @default.
• W2000536375 hasConcept C2780764945 @default.
• W2000536375 hasConcept C501593827 @default.
• W2000536375 hasConcept C55493867 @default.
• W2000536375 hasConcept C71240020 @default.
• W2000536375 hasConceptScore W2000536375C133936738 @default.
• W2000536375 hasConceptScore W2000536375C164126121 @default.
• W2000536375 hasConceptScore W2000536375C185592680 @default.
• W2000536375 hasConceptScore W2000536375C200082930 @default.
• W2000536375 hasConceptScore W2000536375C202751555 @default.
• W2000536375 hasConceptScore W2000536375C2777752497 @default.
• W2000536375 hasConceptScore W2000536375C2778707650 @default.
• W2000536375 hasConceptScore W2000536375C2780764945 @default.
• W2000536375 hasConceptScore W2000536375C501593827 @default.
• W2000536375 hasConceptScore W2000536375C55493867 @default.
• W2000536375 hasConceptScore W2000536375C71240020 @default.
• W2000536375 hasIssue "7" @default.
• W2000536375 hasLocation W20005363751 @default.
• W2000536375 hasLocation W20005363752 @default.
• W2000536375 hasOpenAccess W2000536375 @default.
• W2000536375 hasPrimaryLocation W20005363751 @default.
• W2000536375 hasRelatedWork W1984619218 @default.
• W2000536375 hasRelatedWork W1988556078 @default.
• W2000536375 hasRelatedWork W2032791156 @default.

• next