FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000536767> ?p ?o ?g. }

• W2000536767 endingPage "E305" @default.
• W2000536767 startingPage "E298" @default.
• W2000536767 abstract "Most rodent models of insulin resistance are accompanied by decreased circulating adiponectin levels. Adiponectin treatment improves the metabolic phenotype by increasing fatty acid oxidation in skeletal muscle and suppressing hepatic glucose production. Muscle IGF-I receptor (IGF-IR)-lysine-arginine (MKR) mice expressing dominant-negative mutant IGF-IRs in skeletal muscle are diabetic with insulin resistance in muscle, liver, and adipose tissue. Adiponectin levels are elevated in MKR mice, suggesting an unusual discordance between insulin resistance and adiponectin responsiveness. Therefore, we investigated the metabolic actions of adiponectin in MKR mice. MKR and ob/ob mice were treated both acutely (28 μg/g) and chronically (for 2 wk) with full-length adiponectin. Acute hypoglycemic effects of adiponectin were evident only in ob/ob mice but not in MKR mice. Chronic adiponectin treatment significantly improved both insulin sensitivity and glucose tolerance in ob/ob but not in MKR mice. Adiponectin receptor mRNA levels and adiponectin-stimulated phosphorylation of AMPK in skeletal muscle and liver were similar among MKR, wild-type, and ob/ob mice. Thus MKR mice are adiponectin resistant despite normal expression of adiponectin receptors and normal AMPK phosphorylation in muscle and liver. MKR mice may be a useful model for dissecting relationships between insulin resistance and adiponectin action in regulation of glucose homeostasis." @default.
• W2000536767 created "2016-06-24" @default.
• W2000536767 creator A5004515874 @default.
• W2000536767 creator A5007898120 @default.
• W2000536767 creator A5030291239 @default.
• W2000536767 creator A5030780304 @default.
• W2000536767 creator A5035304169 @default.
• W2000536767 creator A5037167796 @default.
• W2000536767 creator A5041938588 @default.
• W2000536767 creator A5043798434 @default.
• W2000536767 creator A5073948996 @default.
• W2000536767 creator A5077747436 @default.
• W2000536767 date "2006-08-01" @default.
• W2000536767 modified "2023-10-16" @default.
• W2000536767 title "MKR mice are resistant to the metabolic actions of both insulin and adiponectin: discordance between insulin resistance and adiponectin responsiveness" @default.
• W2000536767 cites W1524321743 @default.
• W2000536767 cites W1557165054 @default.
• W2000536767 cites W1587875569 @default.
• W2000536767 cites W1971452427 @default.
• W2000536767 cites W1997978122 @default.
• W2000536767 cites W2010188590 @default.
• W2000536767 cites W2010374889 @default.
• W2000536767 cites W2038280977 @default.
• W2000536767 cites W2042706232 @default.
• W2000536767 cites W2049965571 @default.
• W2000536767 cites W2055378578 @default.
• W2000536767 cites W2065150946 @default.
• W2000536767 cites W2069497802 @default.
• W2000536767 cites W2081393100 @default.
• W2000536767 cites W2091759162 @default.
• W2000536767 cites W2101808846 @default.
• W2000536767 cites W2102677290 @default.
• W2000536767 cites W2108931588 @default.
• W2000536767 cites W2118723490 @default.
• W2000536767 cites W2122328486 @default.
• W2000536767 cites W2123405911 @default.
• W2000536767 cites W2125231550 @default.
• W2000536767 cites W2127934772 @default.
• W2000536767 cites W2132681327 @default.
• W2000536767 cites W2137015334 @default.
• W2000536767 cites W2139315494 @default.
• W2000536767 cites W2146175913 @default.
• W2000536767 cites W2149703192 @default.
• W2000536767 cites W2155574205 @default.
• W2000536767 cites W2156260257 @default.
• W2000536767 cites W2167576798 @default.
• W2000536767 cites W2168761911 @default.
• W2000536767 cites W2169799551 @default.
• W2000536767 cites W2171182656 @default.
• W2000536767 cites W4254261608 @default.
• W2000536767 doi "https://doi.org/10.1152/ajpendo.00319.2005" @default.
• W2000536767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16507604" @default.
• W2000536767 hasPublicationYear "2006" @default.
• W2000536767 type Work @default.
• W2000536767 sameAs 2000536767 @default.
• W2000536767 citedByCount "35" @default.
• W2000536767 countsByYear W20005367672012 @default.
• W2000536767 countsByYear W20005367672013 @default.
• W2000536767 countsByYear W20005367672014 @default.
• W2000536767 countsByYear W20005367672015 @default.
• W2000536767 countsByYear W20005367672016 @default.
• W2000536767 countsByYear W20005367672017 @default.
• W2000536767 countsByYear W20005367672018 @default.
• W2000536767 countsByYear W20005367672019 @default.
• W2000536767 countsByYear W20005367672020 @default.
• W2000536767 countsByYear W20005367672021 @default.
• W2000536767 countsByYear W20005367672022 @default.
• W2000536767 crossrefType "journal-article" @default.
• W2000536767 hasAuthorship W2000536767A5004515874 @default.
• W2000536767 hasAuthorship W2000536767A5007898120 @default.
• W2000536767 hasAuthorship W2000536767A5030291239 @default.
• W2000536767 hasAuthorship W2000536767A5030780304 @default.
• W2000536767 hasAuthorship W2000536767A5035304169 @default.
• W2000536767 hasAuthorship W2000536767A5037167796 @default.
• W2000536767 hasAuthorship W2000536767A5041938588 @default.
• W2000536767 hasAuthorship W2000536767A5043798434 @default.
• W2000536767 hasAuthorship W2000536767A5073948996 @default.
• W2000536767 hasAuthorship W2000536767A5077747436 @default.
• W2000536767 hasConcept C11960822 @default.
• W2000536767 hasConcept C126322002 @default.
• W2000536767 hasConcept C134018914 @default.
• W2000536767 hasConcept C171089720 @default.
• W2000536767 hasConcept C2776782570 @default.
• W2000536767 hasConcept C2777391703 @default.
• W2000536767 hasConcept C2779183219 @default.
• W2000536767 hasConcept C2779306644 @default.
• W2000536767 hasConcept C2779959927 @default.
• W2000536767 hasConcept C2780124434 @default.
• W2000536767 hasConcept C55493867 @default.
• W2000536767 hasConcept C71924100 @default.
• W2000536767 hasConcept C86803240 @default.
• W2000536767 hasConcept C97029542 @default.
• W2000536767 hasConceptScore W2000536767C11960822 @default.
• W2000536767 hasConceptScore W2000536767C126322002 @default.
• W2000536767 hasConceptScore W2000536767C134018914 @default.
• W2000536767 hasConceptScore W2000536767C171089720 @default.
• W2000536767 hasConceptScore W2000536767C2776782570 @default.
• W2000536767 hasConceptScore W2000536767C2777391703 @default.

• next