Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000538996> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2000538996 endingPage "903" @default.
- W2000538996 startingPage "897" @default.
- W2000538996 abstract "Seventy-three patients in whom multiple myeloma could be evaluated were treated with a combination drug protocol (M-2), consisting of melphalan, prednisone, cyclophosphamide, vincristine and BCNU (1,3-bis(2-chloroethyl 1)-1-nitrosourea). All patients were classified according to the clinical staging system of Salmon and Durie; 75 per cent of them were in stage III. Total tumor cell number was calculated according to the method of Salmon. A significant objective remission was obtained in 40 of 46 (87 per cent) previously untreated patients. The median duration of response for this group is presently 20+ months. Twenty-seven of these 40 responders are still in remission. Thirteen of 26 (50 per cent) previously treated patients responded. With eight of these still in remission, the median duration of response for the group is 22+ months. The median times between the first dose and an established response were two and three months for the previously untreated and treated groups, respectively. The duration of remission in the more rapid responders does not appear to be shorter. The response rate does not appear to correlate with the type of immunoglobulin or light chain secreted. One patient, without immunoglobulin secretion, has been in remission for 45+ months, and three with primary amyloid have failed to respond. At this point, it appears that survival time in patients treated with M-2 will be significantly longer than in the earlier group treated at this center with melphalan and prednisone alone." @default.
- W2000538996 created "2016-06-24" @default.
- W2000538996 creator A5014561472 @default.
- W2000538996 creator A5025381409 @default.
- W2000538996 creator A5055019017 @default.
- W2000538996 date "1977-12-01" @default.
- W2000538996 modified "2023-10-16" @default.
- W2000538996 title "Improved survival times in multiple myeloma treated with melphalan, prednisone, cyclophosphamide, vincristine and BCNU: M-2 protocol" @default.
- W2000538996 cites W177715028 @default.
- W2000538996 cites W1965975190 @default.
- W2000538996 cites W1966912003 @default.
- W2000538996 cites W1996469277 @default.
- W2000538996 cites W1998341347 @default.
- W2000538996 cites W2006382315 @default.
- W2000538996 cites W2022589632 @default.
- W2000538996 cites W2034874962 @default.
- W2000538996 cites W2040903318 @default.
- W2000538996 cites W2043566870 @default.
- W2000538996 cites W2056263431 @default.
- W2000538996 cites W2062707603 @default.
- W2000538996 cites W2068222454 @default.
- W2000538996 cites W2077355691 @default.
- W2000538996 cites W2082410795 @default.
- W2000538996 cites W2090352727 @default.
- W2000538996 cites W2143126774 @default.
- W2000538996 cites W4234259363 @default.
- W2000538996 cites W4237712222 @default.
- W2000538996 cites W4293241248 @default.
- W2000538996 cites W4317676163 @default.
- W2000538996 doi "https://doi.org/10.1016/0002-9343(77)90543-5" @default.
- W2000538996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/605911" @default.
- W2000538996 hasPublicationYear "1977" @default.
- W2000538996 type Work @default.
- W2000538996 sameAs 2000538996 @default.
- W2000538996 citedByCount "217" @default.
- W2000538996 countsByYear W20005389962013 @default.
- W2000538996 countsByYear W20005389962015 @default.
- W2000538996 countsByYear W20005389962016 @default.
- W2000538996 countsByYear W20005389962023 @default.
- W2000538996 crossrefType "journal-article" @default.
- W2000538996 hasAuthorship W2000538996A5014561472 @default.
- W2000538996 hasAuthorship W2000538996A5025381409 @default.
- W2000538996 hasAuthorship W2000538996A5055019017 @default.
- W2000538996 hasConcept C126322002 @default.
- W2000538996 hasConcept C141071460 @default.
- W2000538996 hasConcept C146357865 @default.
- W2000538996 hasConcept C151730666 @default.
- W2000538996 hasConcept C2776364478 @default.
- W2000538996 hasConcept C2776694085 @default.
- W2000538996 hasConcept C2776755627 @default.
- W2000538996 hasConcept C2778684742 @default.
- W2000538996 hasConcept C2778720950 @default.
- W2000538996 hasConcept C2779429289 @default.
- W2000538996 hasConcept C71924100 @default.
- W2000538996 hasConcept C86803240 @default.
- W2000538996 hasConcept C90924648 @default.
- W2000538996 hasConceptScore W2000538996C126322002 @default.
- W2000538996 hasConceptScore W2000538996C141071460 @default.
- W2000538996 hasConceptScore W2000538996C146357865 @default.
- W2000538996 hasConceptScore W2000538996C151730666 @default.
- W2000538996 hasConceptScore W2000538996C2776364478 @default.
- W2000538996 hasConceptScore W2000538996C2776694085 @default.
- W2000538996 hasConceptScore W2000538996C2776755627 @default.
- W2000538996 hasConceptScore W2000538996C2778684742 @default.
- W2000538996 hasConceptScore W2000538996C2778720950 @default.
- W2000538996 hasConceptScore W2000538996C2779429289 @default.
- W2000538996 hasConceptScore W2000538996C71924100 @default.
- W2000538996 hasConceptScore W2000538996C86803240 @default.
- W2000538996 hasConceptScore W2000538996C90924648 @default.
- W2000538996 hasIssue "6" @default.
- W2000538996 hasLocation W20005389961 @default.
- W2000538996 hasLocation W20005389962 @default.
- W2000538996 hasOpenAccess W2000538996 @default.
- W2000538996 hasPrimaryLocation W20005389961 @default.
- W2000538996 hasRelatedWork W1980644216 @default.
- W2000538996 hasRelatedWork W2000538996 @default.
- W2000538996 hasRelatedWork W2060816095 @default.
- W2000538996 hasRelatedWork W2160117791 @default.
- W2000538996 hasRelatedWork W2398044595 @default.
- W2000538996 hasRelatedWork W2398340504 @default.
- W2000538996 hasRelatedWork W2400982915 @default.
- W2000538996 hasRelatedWork W2408784808 @default.
- W2000538996 hasRelatedWork W2412100256 @default.
- W2000538996 hasRelatedWork W2414990851 @default.
- W2000538996 hasVolume "63" @default.
- W2000538996 isParatext "false" @default.
- W2000538996 isRetracted "false" @default.
- W2000538996 magId "2000538996" @default.
- W2000538996 workType "article" @default.