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- W2000539334 abstract "Patients with Alzheimer's disease (AD) and major depression have been shown to have overlapping clinical symptoms and biological markers, including decreased concentrations of cerebrospinal fluid (CSF) somatostatin-like immunoreactivity (SLI), which may be related to alterations in the hypothalamic-pituitary-adrenal axis activity. As in prior studies, we found that CSF SLI was significantly decreased in a group of AD patients (N = 49) and a group of elderly patients with major depression (N = 18), as compared with 13 age-matched controls (F[2, 77] = 12.9, p < .001). In the present study, CSF SLI and CSF corticotropin-releasing factor correlated significantly within the group of AD patients (r = 0.49, p < .0004) and almost attained significance in the depressed patients (r = 0.47, p < .07). CSF SLI correlated significantly with urinary free cortisol within each patient group (r = -0.51, p < .03). Clinical measures of dementia severity and depression did not consistently correlate with CSF SLI in either patient group." @default.
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- W2000539334 date "1993-01-01" @default.
- W2000539334 modified "2023-09-25" @default.
- W2000539334 title "CSF somatostatin in Alzheimer's disease and major depression: Relationship to hypothalamic-pituitary-adrenal axis and clinical measures" @default.
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- W2000539334 doi "https://doi.org/10.1016/0306-4530(93)90044-l" @default.
- W2000539334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7903467" @default.
- W2000539334 hasPublicationYear "1993" @default.
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