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- W2000540132 abstract "The effects of deoxyribonucleosides on the intracellular levels of deoxyribonucleoside triphosphates (dNTP) and on the rate of labelled thymidine incorporated into DNA of human phytohaemag-glutinin-stimulated lymphocytes have been studied. Thymidine (10−2–10−6M) expanded the dTTP and reduced dATP and dCTP levels. Deoxycytidine (10−3M) expanded the dCTP level and caused inhibition of [3H] thymidine incorporation into DNA but had no detectable effect on the other dNTP concentrations. Deoxyadenosine (10−3 M) expanded the dATP level, and reduced the other dNTP levels and deoxyguanosine (10−4M) expanded the dGTP level and reduced the dCTP level; both inhibited [3H] thymidine incorporation into DNA. The sensitivity of these cells to the addition of deoxynucleosides to their culture medium indicates that the plasma and tissue levels of nucleosides may profoundly influence DNA synthesis by human cells in vivo." @default.
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- W2000540132 date "1975-08-01" @default.
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- W2000540132 title "The effect of external deoxyribonucleosides on deoxyribonucleoside triphosphate concentrations in human lymphocytes" @default.
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- W2000540132 doi "https://doi.org/10.1016/0006-2952(75)90025-8" @default.
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