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• W2000540743 abstract "Human urotensin II (hU-II) is a cyclic peptide highly expressed in cardiac tissues and blood vessels. hU-II is a potent vasoconstrictor. Recent studies indicate that urotensin II participates in myocardial remodeling after injury. This study was designed to study the role of hU-II in the expression of matrix metalloproteinase-1 (MMP-1) and collagen-1 in human umbilical vein endothelial cells (HUVECs) and underlying intracellular signaling mechanisms.Cultured HUVECs were incubated with hU-II (10 to 80 nM) for 3 to 24 hours. hU-II increased the expression (mRNA and protein) of collagen-1 in a concentration- and time-dependent manner. In contrast, hU-II decreased the expression and activity of MMP-1. Further, hU-II caused the phosphorylation of mitogen-activated protein kinase p42/44 (MAPKp42/44). This effect of hU-II was inhibited by pretreatment of cells with the MEK inhibitor (PD98059, 10 microM). In addition, treatment of cells with PD98059 attenuated protein expression of collagen-1 and MMP-1 elicited by hU-II (P < 0.01 versus hU-II alone).Our observations provide evidence that hU-II modulates the expression of MMP-1 and collagen-1 in HUVECs, and MAPKp42/44 activation may play a signal transduction role in this process." @default.
• W2000540743 created "2016-06-24" @default.
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• W2000540743 date "2004-11-01" @default.
• W2000540743 modified "2023-10-11" @default.
• W2000540743 title "Human Urotensin II Modulates Collagen Synthesis and the Expression of MMP-1 in Human Endothelial Cells" @default.
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• W2000540743 doi "https://doi.org/10.1097/00005344-200411000-00010" @default.
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