FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000541025> ?p ?o ?g. }

• W2000541025 endingPage "84" @default.
• W2000541025 startingPage "78" @default.
• W2000541025 abstract "Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), the most abundant kinase at the postsynaptic density (PSD), is expected to be involved in activity-induced regulation of synaptic properties. CaMKII is activated when it binds calmodulin in the presence of Ca(2+) and, once autophosphorylated on T-286/7, remains active in the absence of Ca(2+) (autonomous form). In the present study we used a quantitative mass spectrometric strategy (iTRAQ) to identify sites on PSD components phosphorylated upon CaMKII activation. Phosphorylation in isolated PSDs was monitored under conditions where CaMKII is: (1) mostly inactive (basal state), (2) active in the presence of Ca(2+), and (3) active in the absence of Ca(2+). The quantification strategy was validated through confirmation of previously described autophosphorylation characteristics of CaMKII. The effectiveness of phosphorylation of major PSD components by the activated CaMKII in the presence and absence of Ca(2+) varied. Most notably, autonomous activity in the absence of Ca(2+) was more effective in the phosphorylation of three residues on SynGAP. Several PSD scaffold proteins were phosphorylated upon activation of CaMKII. The strategy adopted allowed the identification, for the first time, of CaMKII-regulated sites on SAPAPs and Shanks, including three conserved serine residues near the C-termini of SAPAP1, SAPAP2, and SAPAP3. Involvement of CaMKII in the phosphorylation of PSD scaffold proteins suggests a role in activity-induced structural re-organization of the PSD." @default.
• W2000541025 created "2016-06-24" @default.
• W2000541025 creator A5079479032 @default.
• W2000541025 creator A5084090331 @default.
• W2000541025 date "2010-01-01" @default.
• W2000541025 modified "2023-09-27" @default.
• W2000541025 title "Regulation of phosphorylation at the postsynaptic density during different activity states of Ca2+/calmodulin-dependent protein kinase II" @default.
• W2000541025 cites W1499674236 @default.
• W2000541025 cites W1505515840 @default.
• W2000541025 cites W1510318934 @default.
• W2000541025 cites W1527999680 @default.
• W2000541025 cites W1533807820 @default.
• W2000541025 cites W1540233134 @default.
• W2000541025 cites W1979586675 @default.
• W2000541025 cites W1992264197 @default.
• W2000541025 cites W2007309241 @default.
• W2000541025 cites W2013314618 @default.
• W2000541025 cites W2019819425 @default.
• W2000541025 cites W2019873695 @default.
• W2000541025 cites W2020252028 @default.
• W2000541025 cites W2021235911 @default.
• W2000541025 cites W2021652135 @default.
• W2000541025 cites W2035391953 @default.
• W2000541025 cites W2048342840 @default.
• W2000541025 cites W2051702253 @default.
• W2000541025 cites W2052322593 @default.
• W2000541025 cites W2056481979 @default.
• W2000541025 cites W2056655737 @default.
• W2000541025 cites W2058569653 @default.
• W2000541025 cites W2071318481 @default.
• W2000541025 cites W2072087613 @default.
• W2000541025 cites W2074502837 @default.
• W2000541025 cites W2112181124 @default.
• W2000541025 cites W2152874099 @default.
• W2000541025 cites W2167791125 @default.
• W2000541025 doi "https://doi.org/10.1016/j.bbrc.2009.10.167" @default.
• W2000541025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2812614" @default.
• W2000541025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19896464" @default.
• W2000541025 hasPublicationYear "2010" @default.
• W2000541025 type Work @default.
• W2000541025 sameAs 2000541025 @default.
• W2000541025 citedByCount "39" @default.
• W2000541025 countsByYear W20005410252012 @default.
• W2000541025 countsByYear W20005410252013 @default.
• W2000541025 countsByYear W20005410252014 @default.
• W2000541025 countsByYear W20005410252015 @default.
• W2000541025 countsByYear W20005410252016 @default.
• W2000541025 countsByYear W20005410252017 @default.
• W2000541025 countsByYear W20005410252018 @default.
• W2000541025 countsByYear W20005410252020 @default.
• W2000541025 countsByYear W20005410252021 @default.
• W2000541025 countsByYear W20005410252022 @default.
• W2000541025 countsByYear W20005410252023 @default.
• W2000541025 crossrefType "journal-article" @default.
• W2000541025 hasAuthorship W2000541025A5079479032 @default.
• W2000541025 hasAuthorship W2000541025A5084090331 @default.
• W2000541025 hasBestOaLocation W20005410252 @default.
• W2000541025 hasConcept C11960822 @default.
• W2000541025 hasConcept C150109051 @default.
• W2000541025 hasConcept C170493617 @default.
• W2000541025 hasConcept C181199279 @default.
• W2000541025 hasConcept C184235292 @default.
• W2000541025 hasConcept C185592680 @default.
• W2000541025 hasConcept C187541742 @default.
• W2000541025 hasConcept C197341189 @default.
• W2000541025 hasConcept C2776414213 @default.
• W2000541025 hasConcept C29688787 @default.
• W2000541025 hasConcept C55493867 @default.
• W2000541025 hasConcept C86803240 @default.
• W2000541025 hasConcept C87325107 @default.
• W2000541025 hasConcept C95444343 @default.
• W2000541025 hasConcept C97029542 @default.
• W2000541025 hasConceptScore W2000541025C11960822 @default.
• W2000541025 hasConceptScore W2000541025C150109051 @default.
• W2000541025 hasConceptScore W2000541025C170493617 @default.
• W2000541025 hasConceptScore W2000541025C181199279 @default.
• W2000541025 hasConceptScore W2000541025C184235292 @default.
• W2000541025 hasConceptScore W2000541025C185592680 @default.
• W2000541025 hasConceptScore W2000541025C187541742 @default.
• W2000541025 hasConceptScore W2000541025C197341189 @default.
• W2000541025 hasConceptScore W2000541025C2776414213 @default.
• W2000541025 hasConceptScore W2000541025C29688787 @default.
• W2000541025 hasConceptScore W2000541025C55493867 @default.
• W2000541025 hasConceptScore W2000541025C86803240 @default.
• W2000541025 hasConceptScore W2000541025C87325107 @default.
• W2000541025 hasConceptScore W2000541025C95444343 @default.
• W2000541025 hasConceptScore W2000541025C97029542 @default.
• W2000541025 hasIssue "1" @default.
• W2000541025 hasLocation W20005410251 @default.
• W2000541025 hasLocation W20005410252 @default.
• W2000541025 hasLocation W20005410253 @default.
• W2000541025 hasLocation W20005410254 @default.
• W2000541025 hasOpenAccess W2000541025 @default.
• W2000541025 hasPrimaryLocation W20005410251 @default.
• W2000541025 hasRelatedWork W1520436089 @default.
• W2000541025 hasRelatedWork W1640595204 @default.
• W2000541025 hasRelatedWork W1786591675 @default.
• W2000541025 hasRelatedWork W1976050429 @default.

• next