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- W2000542887 abstract "In this paper we develop a mathematical framework for describing multidrug resistance in cancer. To reflect the complexity of the underlying interplay between cancer cells and the therapeutic agent, we assume that the resistance level is a continuous parameter. Our model is written as a system of integro-differential equations that are parameterized by the resistance level. This model incorporates the cell density and mutation dependence. Analysis and simulations of the model demonstrate how the dynamics evolves to a selection of one or more traits corresponding to different levels of resistance. The emerging limit distribution with nonzero variance is the desirable modeling outcome as it represents tumor heterogeneity." @default.
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- W2000542887 date "2014-02-20" @default.
- W2000542887 modified "2023-09-30" @default.
- W2000542887 title "The Impact of Cell Density and Mutations in a Model of Multidrug Resistance in Solid Tumors" @default.
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- W2000542887 doi "https://doi.org/10.1007/s11538-014-9936-8" @default.
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