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• W2000542976 abstract "The acute effects of a single injection of bombesin (BBS) on feeding behavior and serum growth hormone (GH) levels in goldfish were examined. When injected intraperitoneally (IP), BBS (0.5–100 ng/g) caused a dose-dependent decrease in food intake within 30 and 45 min of administration; maximal suppression was achieved at 50 ng/g BBS and was accompanied by an elevation in serum GH levels. Associated with IP injection of BBS was a pronounced spitting out behavior in which food pellets were taken into the oral cavity but immediately expelled. When injected into goldfish deprived of food for 72 h, 50 ng/g BBS was still potent in suppressing feeding behavior and increasing serum GH. Additionally, IP injection of BBS (10 or 100 ng/g) into groups of fish caused a significant increase in circulating serum GH levels at 1.5 h postinjection. Finally, when injected into the third brain ventricle (ICV), 60 ng/g BBS also caused a suppression in food intake and a concomitant increase in serum GH. Groups of fish injected ICV with 5 or 50 ng/g BBS also exhibited a graded increase in serum GH levels at 45 min postinjection. Overall, these data are the first to demonstrate in any lower vertebrate that a neuropeptide acts to suppress food intake and cause concomitant alterations in circulating serum GH levels, following either peripheral or central administration." @default.
• W2000542976 created "2016-06-24" @default.
• W2000542976 creator A5010183444 @default.
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• W2000542976 date "1994-01-01" @default.
• W2000542976 modified "2023-09-26" @default.
• W2000542976 title "Bombesin acts to suppress feeding behavior and alter serum growth hormone in goldfish" @default.
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• W2000542976 doi "https://doi.org/10.1016/0031-9384(94)90011-6" @default.
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