FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000543293> ?p ?o ?g. }

• W2000543293 endingPage "S65" @default.
• W2000543293 startingPage "S60" @default.
• W2000543293 abstract "1. Current immunological monitoring relies heavily on clinical judgment and therapeutic drug levels and does not adequately assess the functional or donor-specific immunosuppression (IS) status of recipients of liver transplantation (LT). 2. Trough levels of drugs are arbitrary and are more clinically relevant for preventing supratherapeutic or subtherapeutic dosing and blood concentrations and for more closely monitoring at-risk populations (children, the elderly, and patients with organ dysfunction). The AUC or the post-dose levels may be more precise, but they have not been used extensively by transplant centers. 3. Data on drug/immune monitoring specific to LT are fairly limited; therefore, clinical practice is often borrowed from experiences with nonhepatic transplantation (mainly renal transplantation). 4. The monitoring of drug levels in patients taking generic immunosuppressants is challenging because the formulations may change with each prescription. The monitoring of drug or antibody levels is not yet clinically available for biological therapies (induction, lymphocyte-depleting, and maintenance agents). 5. Polymorphisms in drug metabolism (cytochrome P450 and P-glycoprotein) may be useful in selecting the initial and maintenance dosages of immunosuppressants and in preventing complications from over or underimmunosuppression. 6. Future immune monitoring assays should be focused on genomic or immunological predispositions and on specific reactivities to donor antigens to guide the appropriate dosing and minimization of IS after LT." @default.
• W2000543293 created "2016-06-24" @default.
• W2000543293 creator A5017698572 @default.
• W2000543293 date "2011-10-26" @default.
• W2000543293 modified "2023-09-25" @default.
• W2000543293 title "Next level of immunosuppression: Drug/immune monitoring" @default.
• W2000543293 cites W1931838354 @default.
• W2000543293 cites W1972672172 @default.
• W2000543293 cites W1978994698 @default.
• W2000543293 cites W1990573727 @default.
• W2000543293 cites W1996544773 @default.
• W2000543293 cites W1998331046 @default.
• W2000543293 cites W2020138838 @default.
• W2000543293 cites W2021775978 @default.
• W2000543293 cites W2025446247 @default.
• W2000543293 cites W2029369423 @default.
• W2000543293 cites W2034728660 @default.
• W2000543293 cites W2038460944 @default.
• W2000543293 cites W2040946990 @default.
• W2000543293 cites W2042250873 @default.
• W2000543293 cites W2042977475 @default.
• W2000543293 cites W2054334209 @default.
• W2000543293 cites W2064784967 @default.
• W2000543293 cites W2068088114 @default.
• W2000543293 cites W2073602500 @default.
• W2000543293 cites W2074637096 @default.
• W2000543293 cites W2075902442 @default.
• W2000543293 cites W2076738911 @default.
• W2000543293 cites W2079190016 @default.
• W2000543293 cites W2082804572 @default.
• W2000543293 cites W2084504787 @default.
• W2000543293 cites W2094424399 @default.
• W2000543293 cites W2096721586 @default.
• W2000543293 cites W2106754485 @default.
• W2000543293 cites W2127884187 @default.
• W2000543293 cites W2134672034 @default.
• W2000543293 cites W2138210929 @default.
• W2000543293 cites W2144956786 @default.
• W2000543293 cites W2165794642 @default.
• W2000543293 cites W2321887612 @default.
• W2000543293 cites W2412416534 @default.
• W2000543293 cites W8361689 @default.
• W2000543293 doi "https://doi.org/10.1002/lt.22385" @default.
• W2000543293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21761551" @default.
• W2000543293 hasPublicationYear "2011" @default.
• W2000543293 type Work @default.
• W2000543293 sameAs 2000543293 @default.
• W2000543293 citedByCount "14" @default.
• W2000543293 countsByYear W20005432932012 @default.
• W2000543293 countsByYear W20005432932013 @default.
• W2000543293 countsByYear W20005432932014 @default.
• W2000543293 countsByYear W20005432932018 @default.
• W2000543293 countsByYear W20005432932019 @default.
• W2000543293 countsByYear W20005432932020 @default.
• W2000543293 countsByYear W20005432932021 @default.
• W2000543293 countsByYear W20005432932022 @default.
• W2000543293 crossrefType "journal-article" @default.
• W2000543293 hasAuthorship W2000543293A5017698572 @default.
• W2000543293 hasConcept C126322002 @default.
• W2000543293 hasConcept C177713679 @default.
• W2000543293 hasConcept C203014093 @default.
• W2000543293 hasConcept C2777288759 @default.
• W2000543293 hasConcept C2780035454 @default.
• W2000543293 hasConcept C2780252810 @default.
• W2000543293 hasConcept C2780272996 @default.
• W2000543293 hasConcept C2909675724 @default.
• W2000543293 hasConcept C2911091166 @default.
• W2000543293 hasConcept C31785415 @default.
• W2000543293 hasConcept C71924100 @default.
• W2000543293 hasConcept C8891405 @default.
• W2000543293 hasConcept C98274493 @default.
• W2000543293 hasConceptScore W2000543293C126322002 @default.
• W2000543293 hasConceptScore W2000543293C177713679 @default.
• W2000543293 hasConceptScore W2000543293C203014093 @default.
• W2000543293 hasConceptScore W2000543293C2777288759 @default.
• W2000543293 hasConceptScore W2000543293C2780035454 @default.
• W2000543293 hasConceptScore W2000543293C2780252810 @default.
• W2000543293 hasConceptScore W2000543293C2780272996 @default.
• W2000543293 hasConceptScore W2000543293C2909675724 @default.
• W2000543293 hasConceptScore W2000543293C2911091166 @default.
• W2000543293 hasConceptScore W2000543293C31785415 @default.
• W2000543293 hasConceptScore W2000543293C71924100 @default.
• W2000543293 hasConceptScore W2000543293C8891405 @default.
• W2000543293 hasConceptScore W2000543293C98274493 @default.
• W2000543293 hasIssue "S3" @default.
• W2000543293 hasLocation W20005432931 @default.
• W2000543293 hasLocation W20005432932 @default.
• W2000543293 hasOpenAccess W2000543293 @default.
• W2000543293 hasPrimaryLocation W20005432931 @default.
• W2000543293 hasRelatedWork W1991601972 @default.
• W2000543293 hasRelatedWork W2000543293 @default.
• W2000543293 hasRelatedWork W2000836995 @default.
• W2000543293 hasRelatedWork W2116212001 @default.
• W2000543293 hasRelatedWork W2136175148 @default.
• W2000543293 hasRelatedWork W2141965224 @default.
• W2000543293 hasRelatedWork W2400924060 @default.
• W2000543293 hasRelatedWork W2402149178 @default.
• W2000543293 hasRelatedWork W2464086138 @default.

• next