FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000544049> ?p ?o ?g. }

• W2000544049 endingPage "531" @default.
• W2000544049 startingPage "526" @default.
• W2000544049 abstract "Aging-related alterations of the ubiquitin proteasome pathway (UPP) have been reported in locomotor skeletal muscle. Specifically, declines in proteasome activity have been observed in the soleus of senescent animals compared to the soleus of young controls. However, the influence of aging on the mRNA levels of key components within the ubiquitin conjugation cascade (UCC) remains unknown. We hypothesized that aged soleus muscle would exhibit downregulated expression of select UCC mRNA and decreased levels of ubiquitin-protein conjugates. To test this postulate, we harvested soleus muscles from 6 and 24-26 month old Fisher 344 rats. Aging resulted in a decline in mRNA expression of two key UCC components in soleus muscle; ubiquitin conjugating enzyme E2(14k) (E2(14k)) and muscle ring finger-1 (MuRF1). Surprisingly, no age-related differences existed in the total content of endogenous ubiquitin-protein conjugates in the soleus muscle. Nonetheless, a selective decrease in the level of ubiquitin-protein conjugates ( approximately 30kDa) was detected in the soleus of senescent animals. These results indicate that the soleus muscle displays a differential mRNA response of select UCC components to aging. Furthermore, the decline in E2(14k) and MuRF1 mRNA levels may contribute to altered substrate degradation by the UCC in the soleus muscle of senescent rats." @default.
• W2000544049 created "2016-06-24" @default.
• W2000544049 creator A5040993657 @default.
• W2000544049 creator A5076743567 @default.
• W2000544049 creator A5077382358 @default.
• W2000544049 date "2005-06-01" @default.
• W2000544049 modified "2023-09-24" @default.
• W2000544049 title "Selective downregulation of ubiquitin conjugation cascade mRNA occurs in the senescent rat soleus muscle" @default.
• W2000544049 cites W1508909871 @default.
• W2000544049 cites W1583148430 @default.
• W2000544049 cites W1607568945 @default.
• W2000544049 cites W1832030339 @default.
• W2000544049 cites W1983919306 @default.
• W2000544049 cites W1984036841 @default.
• W2000544049 cites W1991015655 @default.
• W2000544049 cites W1992427679 @default.
• W2000544049 cites W2021002203 @default.
• W2000544049 cites W2021605503 @default.
• W2000544049 cites W2024946243 @default.
• W2000544049 cites W2027871457 @default.
• W2000544049 cites W2040863926 @default.
• W2000544049 cites W2063803436 @default.
• W2000544049 cites W2068909377 @default.
• W2000544049 cites W2100169627 @default.
• W2000544049 cites W2110704632 @default.
• W2000544049 cites W2124959176 @default.
• W2000544049 cites W2146857090 @default.
• W2000544049 cites W2162506787 @default.
• W2000544049 cites W2162808674 @default.
• W2000544049 cites W2167033587 @default.
• W2000544049 cites W2169448756 @default.
• W2000544049 cites W2171638993 @default.
• W2000544049 cites W4231865486 @default.
• W2000544049 doi "https://doi.org/10.1016/j.exger.2005.04.005" @default.
• W2000544049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15963672" @default.
• W2000544049 hasPublicationYear "2005" @default.
• W2000544049 type Work @default.
• W2000544049 sameAs 2000544049 @default.
• W2000544049 citedByCount "59" @default.
• W2000544049 countsByYear W20005440492012 @default.
• W2000544049 countsByYear W20005440492013 @default.
• W2000544049 countsByYear W20005440492014 @default.
• W2000544049 countsByYear W20005440492015 @default.
• W2000544049 countsByYear W20005440492016 @default.
• W2000544049 countsByYear W20005440492017 @default.
• W2000544049 countsByYear W20005440492018 @default.
• W2000544049 countsByYear W20005440492019 @default.
• W2000544049 countsByYear W20005440492020 @default.
• W2000544049 countsByYear W20005440492021 @default.
• W2000544049 countsByYear W20005440492022 @default.
• W2000544049 crossrefType "journal-article" @default.
• W2000544049 hasAuthorship W2000544049A5040993657 @default.
• W2000544049 hasAuthorship W2000544049A5076743567 @default.
• W2000544049 hasAuthorship W2000544049A5077382358 @default.
• W2000544049 hasConcept C104317684 @default.
• W2000544049 hasConcept C105580179 @default.
• W2000544049 hasConcept C126322002 @default.
• W2000544049 hasConcept C127561419 @default.
• W2000544049 hasConcept C134018914 @default.
• W2000544049 hasConcept C185592680 @default.
• W2000544049 hasConcept C25602115 @default.
• W2000544049 hasConcept C27740335 @default.
• W2000544049 hasConcept C2776104385 @default.
• W2000544049 hasConcept C2779959927 @default.
• W2000544049 hasConcept C522857546 @default.
• W2000544049 hasConcept C55493867 @default.
• W2000544049 hasConcept C71924100 @default.
• W2000544049 hasConcept C86803240 @default.
• W2000544049 hasConcept C95444343 @default.
• W2000544049 hasConceptScore W2000544049C104317684 @default.
• W2000544049 hasConceptScore W2000544049C105580179 @default.
• W2000544049 hasConceptScore W2000544049C126322002 @default.
• W2000544049 hasConceptScore W2000544049C127561419 @default.
• W2000544049 hasConceptScore W2000544049C134018914 @default.
• W2000544049 hasConceptScore W2000544049C185592680 @default.
• W2000544049 hasConceptScore W2000544049C25602115 @default.
• W2000544049 hasConceptScore W2000544049C27740335 @default.
• W2000544049 hasConceptScore W2000544049C2776104385 @default.
• W2000544049 hasConceptScore W2000544049C2779959927 @default.
• W2000544049 hasConceptScore W2000544049C522857546 @default.
• W2000544049 hasConceptScore W2000544049C55493867 @default.
• W2000544049 hasConceptScore W2000544049C71924100 @default.
• W2000544049 hasConceptScore W2000544049C86803240 @default.
• W2000544049 hasConceptScore W2000544049C95444343 @default.
• W2000544049 hasIssue "6" @default.
• W2000544049 hasLocation W20005440491 @default.
• W2000544049 hasLocation W20005440492 @default.
• W2000544049 hasOpenAccess W2000544049 @default.
• W2000544049 hasPrimaryLocation W20005440491 @default.
• W2000544049 hasRelatedWork W1974568996 @default.
• W2000544049 hasRelatedWork W2007330211 @default.
• W2000544049 hasRelatedWork W2020449916 @default.
• W2000544049 hasRelatedWork W2058153407 @default.
• W2000544049 hasRelatedWork W2081376013 @default.
• W2000544049 hasRelatedWork W2082564867 @default.
• W2000544049 hasRelatedWork W2309978229 @default.
• W2000544049 hasRelatedWork W2463478234 @default.
• W2000544049 hasRelatedWork W2893460394 @default.

• next