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- W2000545630 abstract "Recent reports have linked reproductive behavior with severity and age of onset of Alzheimer's Disease (AD) in women but not men, suggesting a gender disparity in disease process which is affected by reproductive functions. We attempted to shed further light on this interaction by examining the relationship of a known genetic risk factor for AD, the presence of the ApoE4 allele, with study participants' reproductive histories. 467 participants in ongoing outpatient AD studies were retrospectively evaluated for apoE status and number of children. SPSS (version 19.0, Chicago, IL) was used for data analyses. Participants' diagnoses were not factored into the analyses. All participants were past reproductive age and belonged to the same generational group. In a logistic regression analysis predicting the probability of having none vs. 1 or more children with covariates of marital status, year of birth, education, and race, there was a significant interaction between gender and ApoE status (P=0.035). The male ApoE4 carrier group included significantly less individuals with children (n = 31, 58%) compared to male ApoE4 non carriers (n = 69, 70%), (X2(2)=4.3, P=0.04, odds ratio, OR=2.4, 95% C.I.: 1.0–5.7) after accounting for covariates. Conversely, there was no relationship between ApoE4 status and whether or not a subject had children in the female group (n = 132, or 63% of the ApoE4 non carrier women, and n = 74, or 70% of the ApoE4 carrier women, n.s.). ApoE4, a known genetic risk factor for AD, negatively affects fertility in men than women. Thus it is more likely to be transmitted to future generations through the maternal line than the paternal line. These findings lend further evidence to a connection between reproductive function and the development and transmission of AD." @default.
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- W2000545630 date "2012-07-01" @default.
- W2000545630 modified "2023-10-16" @default.
- W2000545630 title "P4-080: Presence of the APOE-ε4 allele decreases fertility in men but not women" @default.
- W2000545630 doi "https://doi.org/10.1016/j.jalz.2012.05.1782" @default.
- W2000545630 hasPublicationYear "2012" @default.
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