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- W2000546989 abstract "A total of 1,102 clinical isolates of Gram-negative bacilli was obtained from four hospitals during 1967 and these cultures were tested for sensitivity to ampicillin. Approximately 80% of the strains of <i>Escherichia coli</i> and 90% of the strains of <i>Proteus mirabilis,</i> the two organisms most frequently isolated, were sensitive to ampicillin. Klebsiella-Enterobacter species and <i>Pseudomonas aeruginosa</i> were generally insensitive. Comparison of these results with data obtained in an earlier study with Gram-negative organisms isolated in 1961 showed that there had been no significant increase in the incidence of resistance of Gram-negative bacilli to ampicillin during the period 1961-67. The majority of ampicillin-resistant strains of <i>E. coli</i> isolated in 1967 transferred ampicillin resistance to a sensitive strain of <i>E. coli</i> K12. Only four ampicillin-resistant strains of <i>E. coli</i> isolated in 1961 were available for transferable resistance tests but all four strains transferred ampicillin resistance. Infective or transferable resistance was therefore a feature of ampicillin resistance of certain Gram-negative bacteria before ampicillin became generally available for clinical use." @default.
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- W2000546989 date "1969-11-01" @default.
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- W2000546989 title "Sensitivity of Gram-negative bacilli to ampicillin after six years' clinical use" @default.
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- W2000546989 doi "https://doi.org/10.1136/jcp.22.6.644" @default.
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