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- W2000547573 abstract "A 29-yr-old man was referred for evaluation of progressive bilateral gynecomastia, diminished libido, and impotence. There was no history of exposure to exogenous estrogen, androgen antagonists, or alcohol. Physical examination revealed symmetric gynecomastia (5 X 5 cm), a feminized body contour, and diminished testicular size (9 and 8 mL, respectively). Blood pressure was 130/85 mm Hg. Liver and thyroid functions were normal. The sperm count showed azoospermia. A computerized axial tomographic scan of the abdomen revealed a left adrenal mass (9 X 9 X 10 cm). The diagnosis was made based upon high plasma estrone (E,) and estradiol (EJ levels. After detailed endocrine preoperative testing and catheterization of adrenal veins, the patient underwent left adrenalectomy. An adrenal cortical carcinoma was removed without complications. The weight of the encapsulated adrenal mass was 210 g. Severe nuclear pleomorphism was present, with frequent mitoses and multiple foci of vascular invasion. After resection of the tumor, plasma E, and E, levels fell dramatically. Three months later, gynecomastia had regressed, and the patient had normal sexual intercourse. Four years after surgery, whereas E, and E, remained in the normal range, a chest computed tomography scan detected a lung nodule. Resection and histological analysis of this nodule confirmed the existence of a distant metastasis, and mitotane therapy was started." @default.
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- W2000547573 date "1996-09-01" @default.
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- W2000547573 title "Aromatase expression in a feminizing adrenocortical tumor" @default.
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- W2000547573 doi "https://doi.org/10.1210/jc.81.9.3173" @default.
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