FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000548257> ?p ?o ?g. }

• W2000548257 endingPage "240" @default.
• W2000548257 startingPage "234" @default.
• W2000548257 abstract "Bitter melon (BM; Momordica charantia) has been used as a treatment method for various diseases including cancer and diabetes. The objective of this study was to investigate whether BM has preventive effects against insulin resistance and diabetes and to identify the underlying mechanism by which BM ameliorates insulin resistance in obese and diabetic rats. The rats were separated into three groups as follows: (a) high-fat (HF) diet control, (b) HF diet and 1% BM and (c) HF diet and 3% BM. After 6 weeks of assigned treatments, body weight and food intake were not altered by BM administration. Bitter melon treatment significantly improved glucose tolerance and insulin sensitivity. The levels of proinflammatory cytokines were significantly down-regulated in liver, muscle and epididymal fats from BM-treated rats. The activation of nuclear factor-κB (NF-κB) in the liver and muscle was decreased by BM compared with HF controls. The 3% BM supplementation significantly increased the levels of phospho-insulin receptor substrate-1 (Tyr612) and phospho-Akt (Ser473). It also significantly decreased the levels of phospho-NF-κB (p65) (Ser536) and phospho-c-Jun N-terminal kinase (JNK) (Thr183/Tyr185) in liver, muscle and epididymal fats. The findings of this study indicate that BM exerted preventive effects against insulin resistance and diabetes through the modulation of NF-κB and JNK pathways. Therefore, BM may be useful in the prevention of insulin resistance and diabetes." @default.
• W2000548257 created "2016-06-24" @default.
• W2000548257 creator A5004155763 @default.
• W2000548257 creator A5024434898 @default.
• W2000548257 creator A5027444148 @default.
• W2000548257 creator A5034754913 @default.
• W2000548257 creator A5041894147 @default.
• W2000548257 creator A5044972049 @default.
• W2000548257 creator A5047150082 @default.
• W2000548257 creator A5086311475 @default.
• W2000548257 date "2015-03-01" @default.
• W2000548257 modified "2023-10-18" @default.
• W2000548257 title "Preventive effects of bitter melon (Momordica charantia) against insulin resistance and diabetes are associated with the inhibition of NF-κB and JNK pathways in high-fat-fed OLETF rats" @default.
• W2000548257 cites W1521975179 @default.
• W2000548257 cites W1888719990 @default.
• W2000548257 cites W1910196492 @default.
• W2000548257 cites W1965052750 @default.
• W2000548257 cites W1967248026 @default.
• W2000548257 cites W1968570471 @default.
• W2000548257 cites W1974033843 @default.
• W2000548257 cites W1974370294 @default.
• W2000548257 cites W1974599416 @default.
• W2000548257 cites W1984412270 @default.
• W2000548257 cites W2000054651 @default.
• W2000548257 cites W2022801078 @default.
• W2000548257 cites W2031882974 @default.
• W2000548257 cites W2036904235 @default.
• W2000548257 cites W2037787080 @default.
• W2000548257 cites W2038018821 @default.
• W2000548257 cites W2041272089 @default.
• W2000548257 cites W2045420843 @default.
• W2000548257 cites W2049965571 @default.
• W2000548257 cites W2054027245 @default.
• W2000548257 cites W2067987032 @default.
• W2000548257 cites W2068373977 @default.
• W2000548257 cites W2080860314 @default.
• W2000548257 cites W2084483597 @default.
• W2000548257 cites W2088986234 @default.
• W2000548257 cites W2092429715 @default.
• W2000548257 cites W2095238078 @default.
• W2000548257 cites W2112224922 @default.
• W2000548257 cites W2129316761 @default.
• W2000548257 cites W2130078845 @default.
• W2000548257 cites W2135488901 @default.
• W2000548257 cites W2139600422 @default.
• W2000548257 cites W2140057659 @default.
• W2000548257 cites W2147995249 @default.
• W2000548257 cites W2152377123 @default.
• W2000548257 cites W2159748100 @default.
• W2000548257 cites W2171835251 @default.
• W2000548257 cites W2171873020 @default.
• W2000548257 cites W4210956151 @default.
• W2000548257 cites W4237813261 @default.
• W2000548257 cites W4238497443 @default.
• W2000548257 cites W4249727000 @default.
• W2000548257 doi "https://doi.org/10.1016/j.jnutbio.2014.10.010" @default.
• W2000548257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25488547" @default.
• W2000548257 hasPublicationYear "2015" @default.
• W2000548257 type Work @default.
• W2000548257 sameAs 2000548257 @default.
• W2000548257 citedByCount "48" @default.
• W2000548257 countsByYear W20005482572016 @default.
• W2000548257 countsByYear W20005482572017 @default.
• W2000548257 countsByYear W20005482572018 @default.
• W2000548257 countsByYear W20005482572019 @default.
• W2000548257 countsByYear W20005482572020 @default.
• W2000548257 countsByYear W20005482572021 @default.
• W2000548257 countsByYear W20005482572022 @default.
• W2000548257 countsByYear W20005482572023 @default.
• W2000548257 crossrefType "journal-article" @default.
• W2000548257 hasAuthorship W2000548257A5004155763 @default.
• W2000548257 hasAuthorship W2000548257A5024434898 @default.
• W2000548257 hasAuthorship W2000548257A5027444148 @default.
• W2000548257 hasAuthorship W2000548257A5034754913 @default.
• W2000548257 hasAuthorship W2000548257A5041894147 @default.
• W2000548257 hasAuthorship W2000548257A5044972049 @default.
• W2000548257 hasAuthorship W2000548257A5047150082 @default.
• W2000548257 hasAuthorship W2000548257A5086311475 @default.
• W2000548257 hasConcept C112446052 @default.
• W2000548257 hasConcept C126322002 @default.
• W2000548257 hasConcept C134018914 @default.
• W2000548257 hasConcept C164027704 @default.
• W2000548257 hasConcept C190283241 @default.
• W2000548257 hasConcept C2776914184 @default.
• W2000548257 hasConcept C2777180221 @default.
• W2000548257 hasConcept C2777391703 @default.
• W2000548257 hasConcept C2778686829 @default.
• W2000548257 hasConcept C2779306644 @default.
• W2000548257 hasConcept C55493867 @default.
• W2000548257 hasConcept C555293320 @default.
• W2000548257 hasConcept C556039675 @default.
• W2000548257 hasConcept C71924100 @default.
• W2000548257 hasConcept C75217442 @default.
• W2000548257 hasConcept C86803240 @default.
• W2000548257 hasConceptScore W2000548257C112446052 @default.
• W2000548257 hasConceptScore W2000548257C126322002 @default.
• W2000548257 hasConceptScore W2000548257C134018914 @default.
• W2000548257 hasConceptScore W2000548257C164027704 @default.

• next