FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000548299> ?p ?o ?g. }

• W2000548299 endingPage "1145" @default.
• W2000548299 startingPage "1135" @default.
• W2000548299 abstract "1 Acetylcholine release at the neuromuscular junction relies on rapid, local and transient calcium increase at presynaptic active zones, triggered by the ion influx through voltage-dependent calcium channels (VDCCs) clustered on the presynaptic membrane. Pharmacological investigation of the role of different VDCC subtypes (L-, N-, P/Q- and R-type) in spontaneous and evoked acetylcholine (ACh) release was carried out in adult mouse neuromuscular junctions (NMJs) under normal and pathological conditions. 2 omega-Agatoxin IVA (500 nM), a specific P/Q-type VDCC blocker, abolished end plate potentials (EPPs) in normal NMJs. However, when neurotransmitter release was potentiated by the presence of the K(+) channel blocker 4-aminopyridine (4-AP), an omega-agatoxin IVA- and omega-conotoxin MVIIC-resistant component was detected. This resistant component was only partially sensitive to 1 micro M omega-conotoxin GVIA (N-type VDCC blocker), but insensitive to any other known VDCC blockers. Spontaneous release was dependent only on P/Q-type VDCC in normal NMJs. However, in the presence of 4-AP, it relied on L-type VDCCs too. 3 ACh release from normal NMJs was compared with that of NMJs of mice passively injected with IgGs obtained from patients with Lambert-Eaton myasthenic syndrome (LEMS), a disorder characterized by a compromised neurotransmitter release. Differently from normal NMJs, in LEMS IgGs-treated NMJs an omega-agatoxin IVA-resistant EPP component was detected, which was only partially blocked by calciseptine (1 micro M), a specific L-type VDCC blocker. 4 Altogether, these data demonstrate that multiple VDCC subtypes are present at the mouse NMJ and that a resistant component can be identified under 'pharmacological' and/or 'pathological' conditions." @default.
• W2000548299 created "2016-06-24" @default.
• W2000548299 creator A5003889292 @default.
• W2000548299 creator A5028714047 @default.
• W2000548299 creator A5033805198 @default.
• W2000548299 creator A5043250344 @default.
• W2000548299 creator A5075599210 @default.
• W2000548299 date "2002-08-01" @default.
• W2000548299 modified "2023-10-14" @default.
• W2000548299 title "Calcium channel subtypes contributing to acetylcholine release from normal, 4-aminopyridine-treated and myasthenic syndrome auto-antibodies-affected neuromuscular junctions" @default.
• W2000548299 cites W106022039 @default.
• W2000548299 cites W1526580466 @default.
• W2000548299 cites W1556609980 @default.
• W2000548299 cites W1828854785 @default.
• W2000548299 cites W1886290309 @default.
• W2000548299 cites W1901837579 @default.
• W2000548299 cites W1904956466 @default.
• W2000548299 cites W1971722360 @default.
• W2000548299 cites W1973487122 @default.
• W2000548299 cites W1974623748 @default.
• W2000548299 cites W1976890690 @default.
• W2000548299 cites W1980325410 @default.
• W2000548299 cites W1981034077 @default.
• W2000548299 cites W1984552975 @default.
• W2000548299 cites W1987212226 @default.
• W2000548299 cites W1988937009 @default.
• W2000548299 cites W1999915880 @default.
• W2000548299 cites W2000898141 @default.
• W2000548299 cites W2006111361 @default.
• W2000548299 cites W2008013303 @default.
• W2000548299 cites W2009447116 @default.
• W2000548299 cites W2018540336 @default.
• W2000548299 cites W2019606391 @default.
• W2000548299 cites W2021025567 @default.
• W2000548299 cites W2022103979 @default.
• W2000548299 cites W2028813764 @default.
• W2000548299 cites W2032329869 @default.
• W2000548299 cites W2047461463 @default.
• W2000548299 cites W2047847786 @default.
• W2000548299 cites W2048516082 @default.
• W2000548299 cites W2051428235 @default.
• W2000548299 cites W2052006707 @default.
• W2000548299 cites W2056185727 @default.
• W2000548299 cites W2061056399 @default.
• W2000548299 cites W2061306690 @default.
• W2000548299 cites W2062521762 @default.
• W2000548299 cites W2063370119 @default.
• W2000548299 cites W2063895651 @default.
• W2000548299 cites W2064392861 @default.
• W2000548299 cites W2067935544 @default.
• W2000548299 cites W2068617048 @default.
• W2000548299 cites W2070621678 @default.
• W2000548299 cites W2072844983 @default.
• W2000548299 cites W2082386266 @default.
• W2000548299 cites W2083811631 @default.
• W2000548299 cites W2084165595 @default.
• W2000548299 cites W2085394695 @default.
• W2000548299 cites W2088451235 @default.
• W2000548299 cites W2089868423 @default.
• W2000548299 cites W2093977298 @default.
• W2000548299 cites W2118173900 @default.
• W2000548299 cites W2121365228 @default.
• W2000548299 cites W2126399900 @default.
• W2000548299 cites W2129074604 @default.
• W2000548299 cites W2129654697 @default.
• W2000548299 cites W2143130157 @default.
• W2000548299 cites W2146572660 @default.
• W2000548299 cites W2146681797 @default.
• W2000548299 cites W2147381068 @default.
• W2000548299 cites W2150983664 @default.
• W2000548299 cites W2162597433 @default.
• W2000548299 cites W2163607481 @default.
• W2000548299 cites W2164235945 @default.
• W2000548299 cites W2168337214 @default.
• W2000548299 cites W2187757573 @default.
• W2000548299 cites W2238582832 @default.
• W2000548299 cites W2270756141 @default.
• W2000548299 cites W2293094627 @default.
• W2000548299 cites W4285719527 @default.
• W2000548299 cites W2405175595 @default.
• W2000548299 doi "https://doi.org/10.1038/sj.bjp.0704818" @default.
• W2000548299 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1573446" @default.
• W2000548299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12163346" @default.
• W2000548299 hasPublicationYear "2002" @default.
• W2000548299 type Work @default.
• W2000548299 sameAs 2000548299 @default.
• W2000548299 citedByCount "51" @default.
• W2000548299 countsByYear W20005482992012 @default.
• W2000548299 countsByYear W20005482992013 @default.
• W2000548299 countsByYear W20005482992014 @default.
• W2000548299 countsByYear W20005482992015 @default.
• W2000548299 countsByYear W20005482992016 @default.
• W2000548299 countsByYear W20005482992018 @default.
• W2000548299 countsByYear W20005482992019 @default.
• W2000548299 countsByYear W20005482992020 @default.
• W2000548299 countsByYear W20005482992022 @default.
• W2000548299 countsByYear W20005482992023 @default.
• W2000548299 crossrefType "journal-article" @default.

• next