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- W2000549137 abstract "Viruses replicate inside the cells of an organism and continuously evolve to contend with an ever-changing environment. Many life-threatening diseases, such as AIDS, SARS, hepatitis and some cancers, are caused by viruses. Because viruses have small genome sizes and high mutability, there is currently a lack of and an urgent need for effective treatment for many viral pathogens. One approach that has recently received much attention is aptamer-based therapeutics. Aptamer technology has high target specificity and versatility, i.e., any viral proteins could potentially be targeted. Consequently, new aptamer-based therapeutics have the potential to lead a revolution in the development of anti-infective drugs. Additionally, aptamers can potentially bind any targets and any pathogen that is theoretically amenable to rapid targeting, making aptamers invaluable tools for treating a wide range of diseases. This review will provide a broad, comprehensive overview of viral therapies that use aptamers. The aptamer selection process will be described, followed by an explanation of the potential for treating virus infection by aptamers. Recent progress and prospective use of aptamers against a large variety of human viruses, such as HIV-1, HCV, HBV, SCoV, Rabies virus, HPV, HSV and influenza virus, with particular focus on clinical development of aptamers will also be described. Finally, we will discuss the challenges of advancing antiviral aptamer therapeutics and prospects for future success." @default.
- W2000549137 created "2016-06-24" @default.
- W2000549137 creator A5021999626 @default.
- W2000549137 creator A5046038634 @default.
- W2000549137 creator A5062140331 @default.
- W2000549137 date "2013-11-25" @default.
- W2000549137 modified "2023-09-24" @default.
- W2000549137 title "Aptamer-Based Therapeutics: New Approaches to Combat Human Viral Diseases" @default.
- W2000549137 cites W101981004 @default.
- W2000549137 cites W1484505342 @default.
- W2000549137 cites W1523207280 @default.
- W2000549137 cites W1530538102 @default.
- W2000549137 cites W1540959081 @default.
- W2000549137 cites W1545528913 @default.
- W2000549137 cites W1568328049 @default.
- W2000549137 cites W1575628453 @default.
- W2000549137 cites W1583595519 @default.
- W2000549137 cites W1595507615 @default.
- W2000549137 cites W1609648940 @default.
- W2000549137 cites W163906357 @default.
- W2000549137 cites W1842385511 @default.
- W2000549137 cites W1914838920 @default.
- W2000549137 cites W1940414111 @default.
- W2000549137 cites W1960551808 @default.
- W2000549137 cites W1963897111 @default.
- W2000549137 cites W1964591062 @default.
- W2000549137 cites W1966706806 @default.
- W2000549137 cites W1968372195 @default.
- W2000549137 cites W1969257902 @default.
- W2000549137 cites W1969599147 @default.
- W2000549137 cites W1969604023 @default.
- W2000549137 cites W1970118751 @default.
- W2000549137 cites W1970363346 @default.
- W2000549137 cites W1970630169 @default.
- W2000549137 cites W1971204919 @default.
- W2000549137 cites W1976171351 @default.
- W2000549137 cites W1978202265 @default.
- W2000549137 cites W1979730660 @default.
- W2000549137 cites W1979839950 @default.
- W2000549137 cites W1979913744 @default.
- W2000549137 cites W1983330985 @default.
- W2000549137 cites W1983644993 @default.
- W2000549137 cites W1983704996 @default.
- W2000549137 cites W1985766216 @default.
- W2000549137 cites W1987991458 @default.
- W2000549137 cites W1988049665 @default.
- W2000549137 cites W1989577491 @default.
- W2000549137 cites W1989734124 @default.
- W2000549137 cites W1990539216 @default.
- W2000549137 cites W1993071851 @default.
- W2000549137 cites W1993379751 @default.
- W2000549137 cites W1994853572 @default.
- W2000549137 cites W1995326731 @default.
- W2000549137 cites W1997686479 @default.
- W2000549137 cites W1998421163 @default.
- W2000549137 cites W1998439550 @default.
- W2000549137 cites W1998524058 @default.
- W2000549137 cites W1999869926 @default.
- W2000549137 cites W2000067736 @default.
- W2000549137 cites W2000172089 @default.
- W2000549137 cites W2000675787 @default.
- W2000549137 cites W2000958670 @default.
- W2000549137 cites W2001264233 @default.
- W2000549137 cites W2001601356 @default.
- W2000549137 cites W2002457746 @default.
- W2000549137 cites W2002961521 @default.
- W2000549137 cites W2004198567 @default.
- W2000549137 cites W2008457983 @default.
- W2000549137 cites W2009999437 @default.
- W2000549137 cites W2011363727 @default.
- W2000549137 cites W2012307825 @default.
- W2000549137 cites W2013134024 @default.
- W2000549137 cites W2013905198 @default.
- W2000549137 cites W2015390972 @default.
- W2000549137 cites W2016453064 @default.
- W2000549137 cites W2016921919 @default.
- W2000549137 cites W2018619488 @default.
- W2000549137 cites W2018991730 @default.
- W2000549137 cites W2020629025 @default.
- W2000549137 cites W2020825279 @default.
- W2000549137 cites W2021075601 @default.
- W2000549137 cites W2021985794 @default.
- W2000549137 cites W2024988675 @default.
- W2000549137 cites W2025170735 @default.
- W2000549137 cites W2025549692 @default.
- W2000549137 cites W2025757251 @default.
- W2000549137 cites W2027250176 @default.
- W2000549137 cites W2028316542 @default.
- W2000549137 cites W2028450597 @default.
- W2000549137 cites W2029400685 @default.
- W2000549137 cites W2029910563 @default.
- W2000549137 cites W2031300259 @default.
- W2000549137 cites W2031336681 @default.
- W2000549137 cites W2034037652 @default.
- W2000549137 cites W2036434828 @default.
- W2000549137 cites W2037747289 @default.
- W2000549137 cites W2038195202 @default.
- W2000549137 cites W2041649971 @default.