Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000551045> ?p ?o ?g. }
- W2000551045 endingPage "1074" @default.
- W2000551045 startingPage "1053" @default.
- W2000551045 abstract "c-Kit is a receptor tyrosine kinase that binds stem cell factor (SCF). Structurally, c-Kit contains five immunoglobulin-like domains extracellularly and a catalytic domain divided into two regions by a 77 amino acid insert intracellularly. Studies in white spotting and steel mice have shown that functional SCF and c-Kit are critical in the survival and development of stem cells involved in hematopoiesis, pigmentation and reproduction. Mutations in c-Kit are associated with a variety of human diseases. Interaction of SCF with c-Kit rapidly induces receptor dimerization and increases in autophosphorylation activity. Downstream of c-Kit, multiple signal transduction components are activated, including phosphatidylinositol-3-kinase, Src family members, the JAK/STAT pathway and the Ras-Raf-MAP kinase cascade. Structure-function studies have begun to address the role of these signaling components in SCF-mediated responses. This review will focus on the biochemical mechanism of action of SCF in hematopoietic cells." @default.
- W2000551045 created "2016-06-24" @default.
- W2000551045 creator A5013246710 @default.
- W2000551045 date "1999-10-01" @default.
- W2000551045 modified "2023-10-10" @default.
- W2000551045 title "Early signaling pathways activated by c-Kit in hematopoietic cells" @default.
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