Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000551760> ?p ?o ?g. }
- W2000551760 endingPage "115" @default.
- W2000551760 startingPage "95" @default.
- W2000551760 abstract "During HIV type 1 (HIV-1) entry, trimers of gp120 bind to CD4 and either the CCR5 or CXCR4 coreceptor on the target cell. The stoichiometric parameters associated with HIV-1 entry remain unclear. Important unanswered questions include: how many trimers must attach to CD4 molecules, how many must bind coreceptors, and how many functional gp120 subunits per trimer are required for entry? We performed single round infectivity assays with chimeric viruses and compared the experimental relative infectivity curves with curves generated by mathematical models. Our results indicate that HIV-1 entry requires only a small number of functional spikes (one or two), that Env trimers may function with fewer than three active subunits, and that there is no major difference in the stoichiometric requirements for CCR5 vs. CXCR4 mediated HIV-1 entry into host cells." @default.
- W2000551760 created "2016-06-24" @default.
- W2000551760 creator A5012623658 @default.
- W2000551760 creator A5022966532 @default.
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- W2000551760 creator A5064182369 @default.
- W2000551760 creator A5073437369 @default.
- W2000551760 creator A5089585031 @default.
- W2000551760 date "2001-05-01" @default.
- W2000551760 modified "2023-09-28" @default.
- W2000551760 title "HIV fusion and its inhibition" @default.
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