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- W2000551805 abstract "Two elements are involved in the repair of tissue injury, the replacement of damaged cells and the filling of spaces that result from tissue loss. The lung, unlike other organs, has an abundance of empty spaces in its normal state and, of course, requires them to function. Many forms of lung injury eventuate in pulmonary fibrosis, in which there is both loss and distortion of air spaces resulting in the well-known physiologic abnormalities, restriction of ventilation and impaired gas exchange. On the basis of morphologic approaches, one can infer that at least 4 processes contribute to the remodeling of lung architecture: interstitial thickening, deposition of connective tissue matrix within air spaces, collapse of air spaces, and wound contraction. Although astute morphologists relying on routine histology have long suspected that organization within air spaces and collapse were involved in particular forms of lung fibrosis, 1 Spencer H Chronic interstitial pneumonia. in: Liebow AA The lung. Williams & Wilkins, Baltimore1968: 134-150 Google Scholar tradition has it that pulmonary fibrosis is mainly an interstitial disease. In fact, electron microscopic and immunohistochemical studies carried out in several laboratories in the past 5 years have renewed interest in processes involving the air spaces. 2 Katzenstein A Pathogenesis of “fibrosis” in interstitial pneumonia: an electron microscopic study. Hum Pathol. 1985; 16: 1015-1024 Abstract Full Text PDF PubMed Scopus (123) Google Scholar , 3 Burkhardt A Pathogenesis of pulmonary fibrosis. Hum Pathol. 1986; 17: 971-972 Abstract Full Text PDF PubMed Scopus (13) Google Scholar , 4 Fukuda Y Ferrans VS Schoenberger CI Rennard SI Crystal RG Patterns of pulmonary structural remodeling after experimental paraquat toxicity. Am J Pathol. 1985; 118: 452-475 PubMed Google Scholar , 5 Basset F Ferrans VJ Soler P Takemura T Fukuda Y Crystal RG Intraluminal fibrosis in interstitial lung disorders. Am J Pathol. 1986; 122: 443-461 PubMed Google Scholar , 6 Fukuda Y Ishizaki M Masuda Y et al. The role of intraalveolar fibrosis in the process of pulmonary structural remodeling in patients with diffuse alveolar damage. Am J Pathol. 1987; 126: 171-182 PubMed Google Scholar" @default.
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- W2000551805 title "Patterns of Lung Repair" @default.
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