Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000552200> ?p ?o ?g. }
- W2000552200 endingPage "33" @default.
- W2000552200 startingPage "26" @default.
- W2000552200 abstract "Eph receptor tyrosine kinases and their cell-surface-bound ligands, the ephrins, play key roles in diverse biological processes. Eph receptors comprise the largest family of receptor tyrosine kinases consisting of eight EphA receptors (with five corresponding ephrinA ligands) and six EphB receptors (with three corresponding transmembrane ephrinB ligands). Originally identified as neuronal pathfinding molecules, EphB receptors and ephrinB ligands are later proved to be crucial regulators of vasculogenesis and embryogenesis. More studies indicate that Eph receptors are involved in angiogenesis and tumorigenesis. This study aimed to investigate the expression of EphB2 and EphB4 in breast carcinomas. Semiquantitative RT-PCR and immunohistochemistry were used to examine the expression patterns of EphB2 and EphB4. Clinicopathological and survival correlations were statistically analyzed in a series of 94 breast carcinomas, 9 normal specimens and 4 breast carcinoma cell lines. 1(1%), 16(17%), 29(31%), 48(51%) of the 94 tumors were negative, weak, moderate and strong EphB2 protein expression, respectively. 6(6%), 27(29%), 28(30%), 33(35%) of the tumors were negative, weak, moderate and strong EphB4 expression, respectively. Both EphB2 and EphB4 RTPCR products could be detected in all specimens. Increased EphB2 protein expression was negatively associated with overall survival, and there was a trend that increased EphB2 protein expression was correlated with shorter disease free survival, while EphB4 protein expression was associated with histological grade and stage. EphB4 membrane staining was increased with S phase fraction and associated with DNA aneuploidy. These findings indicate that both EphB2 and EphB4 are involved in the development of breast cancer and that both molecules could be potential predictive markers." @default.
- W2000552200 created "2016-06-24" @default.
- W2000552200 creator A5001097432 @default.
- W2000552200 creator A5023199530 @default.
- W2000552200 creator A5025059110 @default.
- W2000552200 creator A5039174090 @default.
- W2000552200 creator A5054358511 @default.
- W2000552200 creator A5068400806 @default.
- W2000552200 date "2004-03-01" @default.
- W2000552200 modified "2023-10-18" @default.
- W2000552200 title "Expression of Ephb2 and Ephb4 in breast carcinoma" @default.
- W2000552200 cites W1546821979 @default.
- W2000552200 cites W1594899067 @default.
- W2000552200 cites W1860574331 @default.
- W2000552200 cites W1964166386 @default.
- W2000552200 cites W1965950769 @default.
- W2000552200 cites W1972486937 @default.
- W2000552200 cites W1974337230 @default.
- W2000552200 cites W1977219612 @default.
- W2000552200 cites W1986729177 @default.
- W2000552200 cites W1986909516 @default.
- W2000552200 cites W1999379367 @default.
- W2000552200 cites W2002519389 @default.
- W2000552200 cites W2010871781 @default.
- W2000552200 cites W2011983325 @default.
- W2000552200 cites W2014705520 @default.
- W2000552200 cites W2017020944 @default.
- W2000552200 cites W2028163567 @default.
- W2000552200 cites W2035595755 @default.
- W2000552200 cites W2037761545 @default.
- W2000552200 cites W2038115763 @default.
- W2000552200 cites W2038855483 @default.
- W2000552200 cites W2038894508 @default.
- W2000552200 cites W2042113277 @default.
- W2000552200 cites W2050906899 @default.
- W2000552200 cites W2065512985 @default.
- W2000552200 cites W2071520164 @default.
- W2000552200 cites W2082494746 @default.
- W2000552200 cites W2082581761 @default.
- W2000552200 cites W2085532366 @default.
- W2000552200 cites W2087627719 @default.
- W2000552200 cites W2091537773 @default.
- W2000552200 cites W2093467487 @default.
- W2000552200 cites W2093842873 @default.
- W2000552200 cites W2094161067 @default.
- W2000552200 cites W2105320379 @default.
- W2000552200 cites W2107572053 @default.
- W2000552200 cites W2108613636 @default.
- W2000552200 cites W2115732593 @default.
- W2000552200 cites W2122400343 @default.
- W2000552200 cites W2125533727 @default.
- W2000552200 cites W2140067862 @default.
- W2000552200 cites W2144205331 @default.
- W2000552200 cites W2155008209 @default.
- W2000552200 cites W2157594457 @default.
- W2000552200 cites W2162544707 @default.
- W2000552200 cites W2180005201 @default.
- W2000552200 cites W2397932901 @default.
- W2000552200 cites W2409658554 @default.
- W2000552200 cites W2428815793 @default.
- W2000552200 doi "https://doi.org/10.1007/bf02893405" @default.
- W2000552200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15029258" @default.
- W2000552200 hasPublicationYear "2004" @default.
- W2000552200 type Work @default.
- W2000552200 sameAs 2000552200 @default.
- W2000552200 citedByCount "100" @default.
- W2000552200 countsByYear W20005522002012 @default.
- W2000552200 countsByYear W20005522002013 @default.
- W2000552200 countsByYear W20005522002014 @default.
- W2000552200 countsByYear W20005522002015 @default.
- W2000552200 countsByYear W20005522002016 @default.
- W2000552200 countsByYear W20005522002017 @default.
- W2000552200 countsByYear W20005522002018 @default.
- W2000552200 countsByYear W20005522002019 @default.
- W2000552200 countsByYear W20005522002020 @default.
- W2000552200 countsByYear W20005522002021 @default.
- W2000552200 countsByYear W20005522002022 @default.
- W2000552200 countsByYear W20005522002023 @default.
- W2000552200 crossrefType "journal-article" @default.
- W2000552200 hasAuthorship W2000552200A5001097432 @default.
- W2000552200 hasAuthorship W2000552200A5023199530 @default.
- W2000552200 hasAuthorship W2000552200A5025059110 @default.
- W2000552200 hasAuthorship W2000552200A5039174090 @default.
- W2000552200 hasAuthorship W2000552200A5054358511 @default.
- W2000552200 hasAuthorship W2000552200A5068400806 @default.
- W2000552200 hasConcept C101544691 @default.
- W2000552200 hasConcept C121608353 @default.
- W2000552200 hasConcept C142724271 @default.
- W2000552200 hasConcept C150582083 @default.
- W2000552200 hasConcept C170286479 @default.
- W2000552200 hasConcept C170493617 @default.
- W2000552200 hasConcept C19331615 @default.
- W2000552200 hasConcept C203014093 @default.
- W2000552200 hasConcept C204232928 @default.
- W2000552200 hasConcept C2780394083 @default.
- W2000552200 hasConcept C42362537 @default.
- W2000552200 hasConcept C502942594 @default.
- W2000552200 hasConcept C54355233 @default.