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- W200055233 abstract "The formation offilamentsandfibrilsbyspecificpeptidesubstratesis widespreadinnatureandunderliesthepathologyofdiseasessuchas Alzheimer’s and Creutzfelt Jacob (CJD). These processes result from a conformationalswitch which allows polymerisation of the protein usually into highly stable β sheet structures. Here we describe the properties of a peptide derived from a 24 amino acid motif called a leucine rich repeat which under goes such a structural transition. We show that a conserved amide sidechain is required for filament formation and contrast this with the role played by these residues in the native structures of LRR proteins. Interestingly, mutations involving amide residues are often associated with amyloid disease, including predispositions to sporadic CJD. We also describe studies of early events infilament formation by both the LRR peptide and a derivative of Alzheimer β protein 1–42 using the technique of time resolved fluorescent anisotropy." @default.
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- W200055233 date "2005-12-06" @default.
- W200055233 modified "2023-10-14" @default.
- W200055233 title "Structure and Stabilisation of Self-Assembling Peptide Filaments" @default.
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- W200055233 doi "https://doi.org/10.1007/0-306-46890-5_9" @default.
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