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- W2000554117 abstract "Modulatory effect of extract of Stryphnodendron adstringens Mart. (barbatimao) against induced damage by mitomicyn C in mice Stryphnodendron adstringens (Martius) Coville (Leguminosae), popularly known as “barbatimao”, is a medicinal plant that grows in the central Savannas of Brazil. Decoctions or infusions of the stem bark are traditionally used by the na-tive population of Brazil in the treatment of leukorrhea, diarrhoea and as an anti-inflammatory medicine. The aim of this study was to evaluate the antigenotoxicity effect of ethanolic extract of barbatimao (EEB) against induced damage by mitomycin C (MMC) by the bone marrow micronucleus test in mice. Doses of EEB (50 mg/kg, 100 mg/kg e 200 mg/kg) and MMC (4 mg/kg) were administered simultaneously by intraperitonial injection (i.p.) in groups of 5 (five) animals for treatment. The positive control received a MMC i.p. (4 mg/kg) and negative control, distilled and sterilized H 2 O. Cyto-logical preparations were done according Heddle (1973). For all the doses, micronucleated polychromatic erythrocytes frequency (MNPCE) was evaluated at period of 24 h. The obtained results showed no significantly inhibition of MNPCE" @default.
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- W2000554117 date "2006-01-01" @default.
- W2000554117 modified "2023-09-25" @default.
- W2000554117 title "Efeito Modulador do Extrato de Stryphnodendron adstringens Mart. BarbatimoContra Danos Induzidos pela Mitomicina C em Camundongos" @default.
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- W2000554117 doi "https://doi.org/10.5132/jbse.2006.02.007" @default.
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