Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000555016> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2000555016 endingPage "26" @default.
- W2000555016 startingPage "21" @default.
- W2000555016 abstract "The antinociceptive efficacy of systemic- (IV), spinal- (IT), and global supraspinal (ICV)-administered amitriptyline (AMIT) was compared in three different tests for nociception: the hot-plate test, the tail-flick test, and the withdrawal reflex test. Systemic AMIT inhibited the responses in each of the three tests, with distinct dose-effect relationships. Spinal AMIT reduced in a dose-dependent fashion the force of withdrawal to noxious electrical stimulation but was ineffective in the hot-plate test and facilitated the responses in the tail-flick test. Supraspinal AMIT inhibited in a dose-dependent fashion the response to the stimulus of the hot plate, reduced the force of withdrawal after a dose that was effective by the IV route, and again facilitated the responses in the tail-flick test. The results suggest that spinal sites mediate the inhibition of the withdrawal reflex and the supraspinal site the inhibition of the hot-plate test. Two conclusion are drawn: First, AMIT's site of action varies among the pain modalities; and second, augmentation of the reactions can occur. The complex interaction accords with the clinical experience that the benefits of AMIT in pain treatment are hard to predict." @default.
- W2000555016 created "2016-06-24" @default.
- W2000555016 creator A5014578128 @default.
- W2000555016 creator A5015519427 @default.
- W2000555016 creator A5079839143 @default.
- W2000555016 creator A5088438502 @default.
- W2000555016 date "1994-01-01" @default.
- W2000555016 modified "2023-09-23" @default.
- W2000555016 title "Site- and test-dependent antinociceptive efficacy of amitriptyline in rats" @default.
- W2000555016 cites W1969624190 @default.
- W2000555016 cites W1993656420 @default.
- W2000555016 cites W1999133428 @default.
- W2000555016 cites W2000685791 @default.
- W2000555016 cites W2004231664 @default.
- W2000555016 cites W2013512980 @default.
- W2000555016 cites W2014852252 @default.
- W2000555016 cites W2015228718 @default.
- W2000555016 cites W2018212284 @default.
- W2000555016 cites W2018370023 @default.
- W2000555016 cites W2040530406 @default.
- W2000555016 cites W2040725197 @default.
- W2000555016 cites W2040921498 @default.
- W2000555016 cites W2043363666 @default.
- W2000555016 cites W2053084788 @default.
- W2000555016 cites W2067821250 @default.
- W2000555016 cites W2090954037 @default.
- W2000555016 cites W2145899456 @default.
- W2000555016 cites W2165437466 @default.
- W2000555016 cites W2335522108 @default.
- W2000555016 cites W4301719247 @default.
- W2000555016 cites W71328071 @default.
- W2000555016 doi "https://doi.org/10.1016/0091-3057(94)90106-6" @default.
- W2000555016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8115424" @default.
- W2000555016 hasPublicationYear "1994" @default.
- W2000555016 type Work @default.
- W2000555016 sameAs 2000555016 @default.
- W2000555016 citedByCount "22" @default.
- W2000555016 countsByYear W20005550162013 @default.
- W2000555016 countsByYear W20005550162016 @default.
- W2000555016 countsByYear W20005550162020 @default.
- W2000555016 crossrefType "journal-article" @default.
- W2000555016 hasAuthorship W2000555016A5014578128 @default.
- W2000555016 hasAuthorship W2000555016A5015519427 @default.
- W2000555016 hasAuthorship W2000555016A5079839143 @default.
- W2000555016 hasAuthorship W2000555016A5088438502 @default.
- W2000555016 hasConcept C104211972 @default.
- W2000555016 hasConcept C126322002 @default.
- W2000555016 hasConcept C15490471 @default.
- W2000555016 hasConcept C15744967 @default.
- W2000555016 hasConcept C169760540 @default.
- W2000555016 hasConcept C170493617 @default.
- W2000555016 hasConcept C197711040 @default.
- W2000555016 hasConcept C24998067 @default.
- W2000555016 hasConcept C2779918689 @default.
- W2000555016 hasConcept C2780216858 @default.
- W2000555016 hasConcept C42219234 @default.
- W2000555016 hasConcept C52396799 @default.
- W2000555016 hasConcept C542102704 @default.
- W2000555016 hasConcept C71924100 @default.
- W2000555016 hasConcept C83974742 @default.
- W2000555016 hasConcept C98274493 @default.
- W2000555016 hasConceptScore W2000555016C104211972 @default.
- W2000555016 hasConceptScore W2000555016C126322002 @default.
- W2000555016 hasConceptScore W2000555016C15490471 @default.
- W2000555016 hasConceptScore W2000555016C15744967 @default.
- W2000555016 hasConceptScore W2000555016C169760540 @default.
- W2000555016 hasConceptScore W2000555016C170493617 @default.
- W2000555016 hasConceptScore W2000555016C197711040 @default.
- W2000555016 hasConceptScore W2000555016C24998067 @default.
- W2000555016 hasConceptScore W2000555016C2779918689 @default.
- W2000555016 hasConceptScore W2000555016C2780216858 @default.
- W2000555016 hasConceptScore W2000555016C42219234 @default.
- W2000555016 hasConceptScore W2000555016C52396799 @default.
- W2000555016 hasConceptScore W2000555016C542102704 @default.
- W2000555016 hasConceptScore W2000555016C71924100 @default.
- W2000555016 hasConceptScore W2000555016C83974742 @default.
- W2000555016 hasConceptScore W2000555016C98274493 @default.
- W2000555016 hasIssue "1" @default.
- W2000555016 hasLocation W20005550161 @default.
- W2000555016 hasLocation W20005550162 @default.
- W2000555016 hasOpenAccess W2000555016 @default.
- W2000555016 hasPrimaryLocation W20005550161 @default.
- W2000555016 hasRelatedWork W1983928214 @default.
- W2000555016 hasRelatedWork W1992841742 @default.
- W2000555016 hasRelatedWork W2000555016 @default.
- W2000555016 hasRelatedWork W2000919291 @default.
- W2000555016 hasRelatedWork W2063461167 @default.
- W2000555016 hasRelatedWork W2086595071 @default.
- W2000555016 hasRelatedWork W2143143766 @default.
- W2000555016 hasRelatedWork W2289701160 @default.
- W2000555016 hasRelatedWork W2800425031 @default.
- W2000555016 hasRelatedWork W139348647 @default.
- W2000555016 hasVolume "47" @default.
- W2000555016 isParatext "false" @default.
- W2000555016 isRetracted "false" @default.
- W2000555016 magId "2000555016" @default.
- W2000555016 workType "article" @default.