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• W2000555415 abstract "Six male cousins in the Duncan kindred have succumbed to infectious mononucleosis (I.M.), agammaglobulinemia follwing I.M., or lymphoma. We studied 32 persons in the Duncan kindred to determine if additional relatives had the X-linked recessive lymphoproliferative syndrome and defective immunological responses to the Epstein-Barr virus (EBV). A 12-year-old boy, K.M., was discovered who had a history of many infectious diseases, an IgA deficiency, and a progressive increase in IgM to 760 mg/dl following exposure to EBV. The lymphocytes of K.M. spontaneously grew in tissue culture and contained herpes-like viral particles and EBV nuclear antigens. A failure to form antibodies against EBV and mount a T-cell response to EBV-infected B cells may permit uncontrolled B-cell proliferation in males with the syndrome." @default.
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• W2000555415 date "1978-02-01" @default.
• W2000555415 modified "2023-09-30" @default.
• W2000555415 title "Immunodeficiency to the Epstein-Barr virus in the X-linked recessive lymphoproliferative syndrome" @default.
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• W2000555415 doi "https://doi.org/10.1016/0090-1229(78)90066-1" @default.
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