Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000555848> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2000555848 endingPage "173" @default.
- W2000555848 startingPage "169" @default.
- W2000555848 abstract "Sequential methotrexate (Mtx) absorption studies were undertaken in 127 children undergoing treatment for childhood non-T acute lymphoblastic leukaemia (ALL) to determine whether serum drug concentration, clearance and dosage affect event free survival (EFS). Higher serum concentration and area under the plasma concentration curve (AUC) were not associated with an improved EFS. Methotrexate clearance was not found to be of prognostic significance. Patients who tolerated only low 6-mercaptopurine (6-MP) doses because of neutropaenia and those who randomly were prescribed higher doses of Mtx had a lower rate of leukaemia relapse after the completion of therapy. This suggests that the use of maintenance therapy in maximally tolerated doses may be associated with an increased survival in childhood ALL." @default.
- W2000555848 created "2016-06-24" @default.
- W2000555848 creator A5020809266 @default.
- W2000555848 creator A5022943207 @default.
- W2000555848 creator A5052706160 @default.
- W2000555848 creator A5067330530 @default.
- W2000555848 creator A5072052288 @default.
- W2000555848 creator A5080948810 @default.
- W2000555848 creator A5090073231 @default.
- W2000555848 date "1991-07-01" @default.
- W2000555848 modified "2023-10-06" @default.
- W2000555848 title "The influence of serum methotrexate concentrations and drug dosage on outcome in childhood acute lymphoblastic leukaemia" @default.
- W2000555848 cites W1899541887 @default.
- W2000555848 cites W1909437603 @default.
- W2000555848 cites W1965688215 @default.
- W2000555848 cites W1974721564 @default.
- W2000555848 cites W1998287836 @default.
- W2000555848 cites W2004261585 @default.
- W2000555848 cites W2017838616 @default.
- W2000555848 cites W2045371672 @default.
- W2000555848 cites W2057324853 @default.
- W2000555848 cites W2058471639 @default.
- W2000555848 cites W2058710761 @default.
- W2000555848 cites W2083373387 @default.
- W2000555848 cites W2229559212 @default.
- W2000555848 cites W2324850315 @default.
- W2000555848 cites W2338983050 @default.
- W2000555848 cites W307794556 @default.
- W2000555848 doi "https://doi.org/10.1038/bjc.1991.263" @default.
- W2000555848 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1977331" @default.
- W2000555848 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1854617" @default.
- W2000555848 hasPublicationYear "1991" @default.
- W2000555848 type Work @default.
- W2000555848 sameAs 2000555848 @default.
- W2000555848 citedByCount "30" @default.
- W2000555848 countsByYear W20005558482013 @default.
- W2000555848 countsByYear W20005558482014 @default.
- W2000555848 countsByYear W20005558482022 @default.
- W2000555848 crossrefType "journal-article" @default.
- W2000555848 hasAuthorship W2000555848A5020809266 @default.
- W2000555848 hasAuthorship W2000555848A5022943207 @default.
- W2000555848 hasAuthorship W2000555848A5052706160 @default.
- W2000555848 hasAuthorship W2000555848A5067330530 @default.
- W2000555848 hasAuthorship W2000555848A5072052288 @default.
- W2000555848 hasAuthorship W2000555848A5080948810 @default.
- W2000555848 hasAuthorship W2000555848A5090073231 @default.
- W2000555848 hasBestOaLocation W20005558482 @default.
- W2000555848 hasConcept C112705442 @default.
- W2000555848 hasConcept C126322002 @default.
- W2000555848 hasConcept C2776694085 @default.
- W2000555848 hasConcept C2777173762 @default.
- W2000555848 hasConcept C2778397455 @default.
- W2000555848 hasConcept C2778461978 @default.
- W2000555848 hasConcept C2780035454 @default.
- W2000555848 hasConcept C2781059491 @default.
- W2000555848 hasConcept C2781107101 @default.
- W2000555848 hasConcept C2909962599 @default.
- W2000555848 hasConcept C3020081911 @default.
- W2000555848 hasConcept C71924100 @default.
- W2000555848 hasConcept C90924648 @default.
- W2000555848 hasConcept C98274493 @default.
- W2000555848 hasConceptScore W2000555848C112705442 @default.
- W2000555848 hasConceptScore W2000555848C126322002 @default.
- W2000555848 hasConceptScore W2000555848C2776694085 @default.
- W2000555848 hasConceptScore W2000555848C2777173762 @default.
- W2000555848 hasConceptScore W2000555848C2778397455 @default.
- W2000555848 hasConceptScore W2000555848C2778461978 @default.
- W2000555848 hasConceptScore W2000555848C2780035454 @default.
- W2000555848 hasConceptScore W2000555848C2781059491 @default.
- W2000555848 hasConceptScore W2000555848C2781107101 @default.
- W2000555848 hasConceptScore W2000555848C2909962599 @default.
- W2000555848 hasConceptScore W2000555848C3020081911 @default.
- W2000555848 hasConceptScore W2000555848C71924100 @default.
- W2000555848 hasConceptScore W2000555848C90924648 @default.
- W2000555848 hasConceptScore W2000555848C98274493 @default.
- W2000555848 hasIssue "1" @default.
- W2000555848 hasLocation W20005558481 @default.
- W2000555848 hasLocation W20005558482 @default.
- W2000555848 hasLocation W20005558483 @default.
- W2000555848 hasLocation W20005558484 @default.
- W2000555848 hasOpenAccess W2000555848 @default.
- W2000555848 hasPrimaryLocation W20005558481 @default.
- W2000555848 hasRelatedWork W1549755081 @default.
- W2000555848 hasRelatedWork W1967512152 @default.
- W2000555848 hasRelatedWork W1983922888 @default.
- W2000555848 hasRelatedWork W2000555848 @default.
- W2000555848 hasRelatedWork W2013875815 @default.
- W2000555848 hasRelatedWork W2060104469 @default.
- W2000555848 hasRelatedWork W2070843022 @default.
- W2000555848 hasRelatedWork W2333162224 @default.
- W2000555848 hasRelatedWork W2616641857 @default.
- W2000555848 hasRelatedWork W4229655155 @default.
- W2000555848 hasVolume "64" @default.
- W2000555848 isParatext "false" @default.
- W2000555848 isRetracted "false" @default.
- W2000555848 magId "2000555848" @default.
- W2000555848 workType "article" @default.