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- W2000556353 abstract "Macromolecular biosynthesis in monolayer cultures of normal and responder human gingival fibroblasts derived from tissue explants was evaluated in the presence or absence of phenytoin (5μg/ml) from the 5th to the 8th day after plating and a labeling period with 14C-proline (0.2 μCi/ml) for the last 48 hours. Collagenase digestion and hydroxyproline determinations indicated an increase in collagen product. At least part of the increase may have been due to a drug-modulated decrease in collagen degradation. Phenytoin (PHT) also stimulated synthesis of glycosaminoglycan as indicated by an approximately 2-fold increase in sulfate-labeled product. Ultrastructural examination revealed a pronounced change in the protein synthetic apparatus of PHT-treated cells. Tritiated phenytoin bound to fibroblasts and appeared to undergo internalization as indicated by trypsin treatment." @default.
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- W2000556353 date "1987-07-01" @default.
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- W2000556353 title "The effects of phenytoin (5, 5-diphenylhydantoin) on human gingival fibroblasts in culture" @default.
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- W2000556353 doi "https://doi.org/10.1111/j.1600-0765.1987.tb01590.x" @default.
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