FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000556479> ?p ?o ?g. }

• W2000556479 endingPage "721" @default.
• W2000556479 startingPage "714" @default.
• W2000556479 abstract "► We describe pre-ischaemic conditioning in the rat caudate for the first time. ► We show that ischemia-evoked dopamine efflux can be used to measure conditioning. ► We use fast cyclic voltammetry to measure dopamine release in response to ischaemia in real time. ► We show that 10 but not 2 min of pre-ischaemic conditioning evoked tolerance to a second ischaemic event. Fast cyclic voltammetry can be used to measure dopamine release after oxygen and glucose deprivation (OGD) induced anoxic depolarization in vitro. Here we measure dopamine efflux with 1 s time resolution, which is appropriate to measure OGD-evoked dopamine efflux accurately. In the present study, we examined whether OGD-evoked dopamine efflux could be used to show pre-ischaemic conditioning in the rat caudate brain slice. Caudate slices were exposed to 0, 2, or 10 min OGD pre-ischaemic conditioning, then 60 min later exposed to a second OGD event of 15 min duration. We measured the OGD-evoked dopamine efflux using fast cyclic voltammetry and in some experiments caudate dopamine and DOPAC tissue levels were measured using HPLC and 20 μm cryostat sections were Nissl stained to indicate neuronal loss. We found that 10 but not 2 min OGD pre-ischaemic conditioning resulted in a longer time to onset of OGD-evoked dopamine efflux on the main OGD event (475 ± 31 and 287 ± 30 s for 10 Vs 0 min pre-ischaemic conditioning respectively). Further, 10 min OGD pre-ischaemic conditioning resulted in less dopamine efflux on the second OGD event (4.23 ± 1.12 and 8.14 ± 0.82 μM for 10 Vs 0 min pre-ischaemic conditioning respectively), despite these slices having similar tissue dopamine content and DOPAC/DA ratio, and the rate of dopamine release was slower in the main OGD event (21 ± 5 and 74 ± 8nM/s for 10 Vs 0 min pre-ischaemic conditioning respectively). These data suggest that 10 min OGD pre-ischaemic conditioning can evoke tolerance to a second OGD event and that voltammetric recording of OGD-evoked dopamine efflux is a useful model of pre-ischaemic conditioning in neuronal tissue." @default.
• W2000556479 created "2016-06-24" @default.
• W2000556479 creator A5020658063 @default.
• W2000556479 creator A5023590436 @default.
• W2000556479 creator A5024187061 @default.
• W2000556479 creator A5088400104 @default.
• W2000556479 date "2011-10-01" @default.
• W2000556479 modified "2023-09-23" @default.
• W2000556479 title "Effect of pre-ischaemic conditioning on hypoxic depolarization of dopamine efflux in the rat caudate brain slice measured in real-time with fast cyclic voltammetry" @default.
• W2000556479 cites W1209665789 @default.
• W2000556479 cites W1966577064 @default.
• W2000556479 cites W1969635685 @default.
• W2000556479 cites W1973383680 @default.
• W2000556479 cites W1973449790 @default.
• W2000556479 cites W1976768880 @default.
• W2000556479 cites W1985091985 @default.
• W2000556479 cites W1991094289 @default.
• W2000556479 cites W1997764161 @default.
• W2000556479 cites W1998083451 @default.
• W2000556479 cites W2005304266 @default.
• W2000556479 cites W2007283865 @default.
• W2000556479 cites W2008762813 @default.
• W2000556479 cites W2009699988 @default.
• W2000556479 cites W2009812062 @default.
• W2000556479 cites W2016981191 @default.
• W2000556479 cites W2021680546 @default.
• W2000556479 cites W2025754202 @default.
• W2000556479 cites W2034171971 @default.
• W2000556479 cites W2036927957 @default.
• W2000556479 cites W2041407419 @default.
• W2000556479 cites W2041998323 @default.
• W2000556479 cites W2069354437 @default.
• W2000556479 cites W2071164056 @default.
• W2000556479 cites W2078143043 @default.
• W2000556479 cites W2078800944 @default.
• W2000556479 cites W2080718222 @default.
• W2000556479 cites W2083467935 @default.
• W2000556479 cites W2085904032 @default.
• W2000556479 cites W2087059874 @default.
• W2000556479 cites W2087849551 @default.
• W2000556479 cites W2096250407 @default.
• W2000556479 cites W2099816146 @default.
• W2000556479 cites W2111580310 @default.
• W2000556479 cites W2127419413 @default.
• W2000556479 cites W2144232114 @default.
• W2000556479 cites W2144918294 @default.
• W2000556479 cites W2145906435 @default.
• W2000556479 cites W2146217294 @default.
• W2000556479 cites W2166660871 @default.
• W2000556479 cites W2169160949 @default.
• W2000556479 cites W2171942027 @default.
• W2000556479 cites W2749212728 @default.
• W2000556479 cites W4210973470 @default.
• W2000556479 cites W4242903617 @default.
• W2000556479 doi "https://doi.org/10.1016/j.neuint.2011.06.020" @default.
• W2000556479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21762742" @default.
• W2000556479 hasPublicationYear "2011" @default.
• W2000556479 type Work @default.
• W2000556479 sameAs 2000556479 @default.
• W2000556479 citedByCount "7" @default.
• W2000556479 countsByYear W20005564792012 @default.
• W2000556479 countsByYear W20005564792013 @default.
• W2000556479 countsByYear W20005564792021 @default.
• W2000556479 crossrefType "journal-article" @default.
• W2000556479 hasAuthorship W2000556479A5020658063 @default.
• W2000556479 hasAuthorship W2000556479A5023590436 @default.
• W2000556479 hasAuthorship W2000556479A5024187061 @default.
• W2000556479 hasAuthorship W2000556479A5088400104 @default.
• W2000556479 hasConcept C126322002 @default.
• W2000556479 hasConcept C134018914 @default.
• W2000556479 hasConcept C185592680 @default.
• W2000556479 hasConcept C4141045 @default.
• W2000556479 hasConcept C42219234 @default.
• W2000556479 hasConcept C513476851 @default.
• W2000556479 hasConcept C541997718 @default.
• W2000556479 hasConcept C71924100 @default.
• W2000556479 hasConceptScore W2000556479C126322002 @default.
• W2000556479 hasConceptScore W2000556479C134018914 @default.
• W2000556479 hasConceptScore W2000556479C185592680 @default.
• W2000556479 hasConceptScore W2000556479C4141045 @default.
• W2000556479 hasConceptScore W2000556479C42219234 @default.
• W2000556479 hasConceptScore W2000556479C513476851 @default.
• W2000556479 hasConceptScore W2000556479C541997718 @default.
• W2000556479 hasConceptScore W2000556479C71924100 @default.
• W2000556479 hasIssue "5" @default.
• W2000556479 hasLocation W20005564791 @default.
• W2000556479 hasLocation W20005564792 @default.
• W2000556479 hasOpenAccess W2000556479 @default.
• W2000556479 hasPrimaryLocation W20005564791 @default.
• W2000556479 hasRelatedWork W1969139594 @default.
• W2000556479 hasRelatedWork W1979059193 @default.
• W2000556479 hasRelatedWork W2015327999 @default.
• W2000556479 hasRelatedWork W2034255477 @default.
• W2000556479 hasRelatedWork W2038081958 @default.
• W2000556479 hasRelatedWork W2062579683 @default.
• W2000556479 hasRelatedWork W2089103608 @default.
• W2000556479 hasRelatedWork W2120946541 @default.
• W2000556479 hasRelatedWork W2163744984 @default.

• next