FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000558721> ?p ?o ?g. }

• W2000558721 endingPage "191" @default.
• W2000558721 startingPage "186" @default.
• W2000558721 abstract "The aim of the study was to investigate serum concentrations of interleukin (IL)-17 and IL-17-inducing cytokines IL-23 and transforming growth factor (TGF)-β, as well as IL-17 single nucleotide polymorphism (SNP) rs2275913 in patients with primary antiphospholipid syndrome (PAPS). We studied fifty patients with PAPS and fifty age- and sex-matched healthy controls. The cytokine levels were measured by ELISA, while the rs2275913 SNP located in promoter region of IL-17 gene was genotyped using real-time PCR. The significantly higher levels of IL-17 (p=0.002), IL-23 (p<0.001) and TGF-β (p=0.042) were found in PAPS patients (median 13.1, 9.4, and 125.6 pg/ml, respectively) compared to the control group (6.8, 4.9 and 44.4 pg/ml). There was a significant positive correlation between concentrations of IL-17 and IL-23 (r=0.540, p<0.001), but not between those of IL-17 and TGF-β. No statistically significant differences were observed in the distribution of genotypes and alleles of the IL-17 rs2275913 variants in patients with PAPS compared to healthy subjects. The blood concentrations of IL-17 did not differ in subjects with different rs2275913 genotypes or patients with or without antiphospholipid antibodies. Finally, a trend toward higher IL-17 levels (p=0.063) and the significantly higher IL-17 concentrations (p=0.012) were observed in PAPS patients with deep vein thrombosis and thrombocytopenia, respectively. These data demonstrate that IL-23/IL-17 axis, stimulated independently of TGF-β increase IL-17A gene polymorphism and antiphospholipid antibody production, might contribute to vascular manifestations of PAPS." @default.
• W2000558721 created "2016-06-24" @default.
• W2000558721 creator A5001081800 @default.
• W2000558721 creator A5002157110 @default.
• W2000558721 creator A5020278481 @default.
• W2000558721 creator A5021652310 @default.
• W2000558721 creator A5068986068 @default.
• W2000558721 creator A5070648885 @default.
• W2000558721 creator A5082792260 @default.
• W2000558721 date "2013-02-01" @default.
• W2000558721 modified "2023-10-05" @default.
• W2000558721 title "Increased activity of interleukin-23/interleukin-17 cytokine axis in primary antiphospholipid syndrome" @default.
• W2000558721 cites W1518759830 @default.
• W2000558721 cites W1548931116 @default.
• W2000558721 cites W1553271826 @default.
• W2000558721 cites W1590848615 @default.
• W2000558721 cites W1595770568 @default.
• W2000558721 cites W1697354033 @default.
• W2000558721 cites W1974520709 @default.
• W2000558721 cites W1974640470 @default.
• W2000558721 cites W1980962072 @default.
• W2000558721 cites W1981714996 @default.
• W2000558721 cites W1983899969 @default.
• W2000558721 cites W1998761103 @default.
• W2000558721 cites W1998895238 @default.
• W2000558721 cites W1999555834 @default.
• W2000558721 cites W2002327634 @default.
• W2000558721 cites W2002627189 @default.
• W2000558721 cites W2004868771 @default.
• W2000558721 cites W2010605836 @default.
• W2000558721 cites W2013507458 @default.
• W2000558721 cites W2015858332 @default.
• W2000558721 cites W2018166175 @default.
• W2000558721 cites W2018350051 @default.
• W2000558721 cites W2021168296 @default.
• W2000558721 cites W2023398296 @default.
• W2000558721 cites W2046442721 @default.
• W2000558721 cites W2047819904 @default.
• W2000558721 cites W2049278423 @default.
• W2000558721 cites W2050794737 @default.
• W2000558721 cites W2052219561 @default.
• W2000558721 cites W2054330426 @default.
• W2000558721 cites W2070391335 @default.
• W2000558721 cites W2071360012 @default.
• W2000558721 cites W2072644860 @default.
• W2000558721 cites W2073263219 @default.
• W2000558721 cites W2073441708 @default.
• W2000558721 cites W2076504656 @default.
• W2000558721 cites W2088162411 @default.
• W2000558721 cites W2088737310 @default.
• W2000558721 cites W2108130589 @default.
• W2000558721 cites W2112866067 @default.
• W2000558721 cites W2113577022 @default.
• W2000558721 cites W2116553220 @default.
• W2000558721 cites W2125383321 @default.
• W2000558721 cites W2126874760 @default.
• W2000558721 cites W2134496632 @default.
• W2000558721 cites W2149295409 @default.
• W2000558721 cites W2150005144 @default.
• W2000558721 cites W2154654152 @default.
• W2000558721 cites W2155779547 @default.
• W2000558721 cites W2160359623 @default.
• W2000558721 cites W2162364719 @default.
• W2000558721 cites W2162450874 @default.
• W2000558721 cites W2276292771 @default.
• W2000558721 cites W4211023937 @default.
• W2000558721 doi "https://doi.org/10.1016/j.imbio.2012.03.002" @default.
• W2000558721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22559912" @default.
• W2000558721 hasPublicationYear "2013" @default.
• W2000558721 type Work @default.
• W2000558721 sameAs 2000558721 @default.
• W2000558721 citedByCount "19" @default.
• W2000558721 countsByYear W20005587212013 @default.
• W2000558721 countsByYear W20005587212014 @default.
• W2000558721 countsByYear W20005587212015 @default.
• W2000558721 countsByYear W20005587212016 @default.
• W2000558721 countsByYear W20005587212017 @default.
• W2000558721 countsByYear W20005587212018 @default.
• W2000558721 countsByYear W20005587212019 @default.
• W2000558721 countsByYear W20005587212020 @default.
• W2000558721 countsByYear W20005587212021 @default.
• W2000558721 countsByYear W20005587212022 @default.
• W2000558721 crossrefType "journal-article" @default.
• W2000558721 hasAuthorship W2000558721A5001081800 @default.
• W2000558721 hasAuthorship W2000558721A5002157110 @default.
• W2000558721 hasAuthorship W2000558721A5020278481 @default.
• W2000558721 hasAuthorship W2000558721A5021652310 @default.
• W2000558721 hasAuthorship W2000558721A5068986068 @default.
• W2000558721 hasAuthorship W2000558721A5070648885 @default.
• W2000558721 hasAuthorship W2000558721A5082792260 @default.
• W2000558721 hasConcept C104317684 @default.
• W2000558721 hasConcept C126322002 @default.
• W2000558721 hasConcept C134018914 @default.
• W2000558721 hasConcept C135763542 @default.
• W2000558721 hasConcept C139275648 @default.
• W2000558721 hasConcept C153209595 @default.
• W2000558721 hasConcept C159654299 @default.
• W2000558721 hasConcept C187316574 @default.

• next