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- W2000558730 endingPage "1093" @default.
- W2000558730 startingPage "1081" @default.
- W2000558730 abstract "Clamp protein or clamp, initially identified as the processivity factor of the replicative DNA polymerase, is indispensable for the timely and faithful replication of DNA genome. Clamp encircles duplex DNA and physically interacts with DNA polymerase. Clamps from different organisms share remarkable similarities in both structure and function. Loading of clamp onto DNA requires the activity of clamp loader. Although all clamp loaders act by converting the chemical energy derived from ATP hydrolysis to mechanical force, intriguing differences exist in the mechanistic details of clamp loading. The structure and function of clamp in normal and translesion DNA synthesis has been subjected to extensive investigations. This review summarizes the current understanding of clamps from three kingdoms of life and the mechanism of loading by their cognate clamp loaders. We also discuss the recent findings on the interactions between clamp and DNA, as well as between clamp and DNA polymerase (both the replicative and specialized DNA polymerases). Lastly the role of clamp in modulating polymerase exchange is discussed in the context of translesion DNA synthesis." @default.
- W2000558730 created "2016-06-24" @default.
- W2000558730 creator A5015010872 @default.
- W2000558730 creator A5090254750 @default.
- W2000558730 date "2010-05-01" @default.
- W2000558730 modified "2023-10-08" @default.
- W2000558730 title "Processivity factor of DNA polymerase and its expanding role in normal and translesion DNA synthesis" @default.
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