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- W2000558846 abstract "4-[14C]HAD was rapidly metabolized (99% after 5 min) by hepatocytes from phenobarbitaltreated rats. An array of phase I metabolites was formed, variously involving one and two reductions, hydroxylation, hydration and hydroxylation plus one or two reductions. Some of the metabolites were identified by synthesis and others tentatively by mass spectrometry. After 10 min, ≈30% of the original radioactivity was present in HAD glucuronide and, after 15 min, ≈60% was present in the total glucuronide fraction which contained several components. Only one of the phase I metabolites (2-hydroxy-HAD) exhibited significant aromatase inhibitory activity (45% of that of HAD)." @default.
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- W2000558846 date "1986-02-01" @default.
- W2000558846 modified "2023-09-28" @default.
- W2000558846 title "Metabolism of 4-hydroxyandrost-4-ene-3,17-dione by rat hepatocytes" @default.
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- W2000558846 doi "https://doi.org/10.1016/0022-4731(86)90127-5" @default.
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