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- W2000559850 endingPage "1529" @default.
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- W2000559850 abstract "This review article by Peter McKinnon discusses the latest progress in understanding the complexity of DNA damage and related repair pathways in the nervous system. The piece highlights DNA damage/repair in both normal course of brain development and in aging, and discusses possible dysfunction of this mechanism in disease as uniquely faced by postmitotic neurons in the brain. Active maintenance of genome stability is a prerequisite for the development and function of the nervous system. The high replication index during neurogenesis and the long life of mature neurons highlight the need for efficient cellular programs to safeguard genetic fidelity. Multiple DNA damage response pathways ensure that replication stress and other types of DNA lesions, such as oxidative damage, do not affect neural homeostasis. Numerous human neurologic syndromes result from defective DNA damage signaling and compromised genome integrity. These syndromes can involve different neuropathology, which highlights the diverse maintenance roles that are required for genome stability in the nervous system. Understanding how DNA damage signaling pathways promote neural development and preserve homeostasis is essential for understanding fundamental brain function." @default.
- W2000559850 created "2016-06-24" @default.
- W2000559850 creator A5025541556 @default.
- W2000559850 date "2013-10-28" @default.
- W2000559850 modified "2023-10-06" @default.
- W2000559850 title "Maintaining genome stability in the nervous system" @default.
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