FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000559897> ?p ?o ?g. }

• W2000559897 endingPage "F805" @default.
• W2000559897 startingPage "F797" @default.
• W2000559897 abstract "Renal concentrating ability is known to be impaired with aging. The antidiuretic hormone AVP plays an important role in renal water excretion by regulating the membrane insertion and abundance of the water channel aquaporin-2 (AQP2); this effect is primarily mediated via the V2 subtype of the AVP receptor (V2R). This study evaluated the hypothesis that decreased renal sensitivity to AVP, with subsequent altered renal AQP2 expression, contributes to the reduced urinary concentrating ability with aging. Our results show that under baseline conditions, urine osmolality is significantly lower in aged Fischer 344 and Brown-Norway F1 hybrid (F344BN) rats despite equivalent plasma AVP concentrations as in young rats. Levels of kidney V2R mRNA expression and AQP2 abundances were also significantly decreased in aged F344BN rats, as was AQP2 immunostaining in collecting duct cells. In response to moderate water restriction, urine osmolality increased by significantly lesser amounts in aged F344BN rats compared with young rats despite similar increases in plasma AVP levels. Moderate water restriction induced equivalent relative increases in renal AQP2 abundances in all age groups but resulted in significantly lower abundances in total kidney AQP2 protein in aged compared with young F344BN rats. These results therefore demonstrate a functional impairment of renal concentrating ability in aged F344BN rats that is not due to impaired secretion of AVP but rather appears to be related to impaired responsiveness of the kidney to AVP that is secondary, at least in part, to a downregulation of renal V2R expression and AQP2 abundance." @default.
• W2000559897 created "2016-06-24" @default.
• W2000559897 creator A5018524876 @default.
• W2000559897 creator A5054888466 @default.
• W2000559897 creator A5063006329 @default.
• W2000559897 date "2004-10-01" @default.
• W2000559897 modified "2023-10-16" @default.
• W2000559897 title "Downregulation of renal vasopressin V2 receptor and aquaporin-2 expression parallels age-associated defects in urine concentration" @default.
• W2000559897 cites W1487839426 @default.
• W2000559897 cites W1586219219 @default.
• W2000559897 cites W1639251217 @default.
• W2000559897 cites W1966725029 @default.
• W2000559897 cites W1969365907 @default.
• W2000559897 cites W1972361162 @default.
• W2000559897 cites W1983863376 @default.
• W2000559897 cites W1984208216 @default.
• W2000559897 cites W1992479042 @default.
• W2000559897 cites W1992838179 @default.
• W2000559897 cites W1994266582 @default.
• W2000559897 cites W1994626731 @default.
• W2000559897 cites W1997623901 @default.
• W2000559897 cites W2009917793 @default.
• W2000559897 cites W2014094059 @default.
• W2000559897 cites W2015326966 @default.
• W2000559897 cites W2015403519 @default.
• W2000559897 cites W2016881921 @default.
• W2000559897 cites W2017625940 @default.
• W2000559897 cites W2024185951 @default.
• W2000559897 cites W2041275308 @default.
• W2000559897 cites W2042889968 @default.
• W2000559897 cites W2043757191 @default.
• W2000559897 cites W2045096135 @default.
• W2000559897 cites W2049711172 @default.
• W2000559897 cites W2053231261 @default.
• W2000559897 cites W2063428402 @default.
• W2000559897 cites W2069327462 @default.
• W2000559897 cites W2076069431 @default.
• W2000559897 cites W2082414348 @default.
• W2000559897 cites W2091718948 @default.
• W2000559897 cites W2104075229 @default.
• W2000559897 cites W2104449628 @default.
• W2000559897 cites W2138815839 @default.
• W2000559897 cites W2145437687 @default.
• W2000559897 cites W2154745188 @default.
• W2000559897 cites W2156265674 @default.
• W2000559897 cites W2180147188 @default.
• W2000559897 cites W2187055482 @default.
• W2000559897 cites W2198535099 @default.
• W2000559897 cites W2281410802 @default.
• W2000559897 cites W2299411513 @default.
• W2000559897 cites W2302194690 @default.
• W2000559897 cites W23171315 @default.
• W2000559897 cites W2335728918 @default.
• W2000559897 cites W2338060763 @default.
• W2000559897 cites W2340435310 @default.
• W2000559897 cites W2400133711 @default.
• W2000559897 cites W2462011998 @default.
• W2000559897 cites W2466647376 @default.
• W2000559897 cites W339788261 @default.
• W2000559897 doi "https://doi.org/10.1152/ajprenal.00403.2003" @default.
• W2000559897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15213068" @default.
• W2000559897 hasPublicationYear "2004" @default.
• W2000559897 type Work @default.
• W2000559897 sameAs 2000559897 @default.
• W2000559897 citedByCount "49" @default.
• W2000559897 countsByYear W20005598972012 @default.
• W2000559897 countsByYear W20005598972013 @default.
• W2000559897 countsByYear W20005598972014 @default.
• W2000559897 countsByYear W20005598972016 @default.
• W2000559897 countsByYear W20005598972017 @default.
• W2000559897 countsByYear W20005598972018 @default.
• W2000559897 countsByYear W20005598972019 @default.
• W2000559897 countsByYear W20005598972020 @default.
• W2000559897 countsByYear W20005598972021 @default.
• W2000559897 countsByYear W20005598972022 @default.
• W2000559897 countsByYear W20005598972023 @default.
• W2000559897 crossrefType "journal-article" @default.
• W2000559897 hasAuthorship W2000559897A5018524876 @default.
• W2000559897 hasAuthorship W2000559897A5054888466 @default.
• W2000559897 hasAuthorship W2000559897A5063006329 @default.
• W2000559897 hasConcept C104317684 @default.
• W2000559897 hasConcept C126322002 @default.
• W2000559897 hasConcept C127413603 @default.
• W2000559897 hasConcept C127561419 @default.
• W2000559897 hasConcept C134018914 @default.
• W2000559897 hasConcept C170493617 @default.
• W2000559897 hasConcept C185592680 @default.
• W2000559897 hasConcept C201289731 @default.
• W2000559897 hasConcept C2775845273 @default.
• W2000559897 hasConcept C2776370428 @default.
• W2000559897 hasConcept C2776885963 @default.
• W2000559897 hasConcept C2778534349 @default.
• W2000559897 hasConcept C2779420931 @default.
• W2000559897 hasConcept C2780091579 @default.
• W2000559897 hasConcept C2780762869 @default.
• W2000559897 hasConcept C55493867 @default.
• W2000559897 hasConcept C71924100 @default.
• W2000559897 hasConcept C77411442 @default.

• next