FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000560437> ?p ?o ?g. }

• W2000560437 endingPage "257" @default.
• W2000560437 startingPage "237" @default.
• W2000560437 abstract "Mice immunized with purified AChR (T. californica) invariably form anti-AChR antibodies and often develop a condition of extreme muscular weakness and flaccid paralysis. Pharmacological, physiological, and ultrastructural studies indicate that the pathophysiology of EMG in the mouse closely resembles that of human MG. The single episode of muscular weakness typically found in mouse EMG differs from the acute phase of rat EMG in that macrophages and other phagocytes do not appear to play an active role in the destruction of the neuromuscular junction. The frequency of paralysis in mice immunized with AChR is highly strain dependent and is not attributable to polymorphisms with respect to susceptibility to cholinergic blockade. The incidence of paralysis does not correlate with the magnitude of the humoral response to either T. californica or mouse AChR. Because both paralyzed and nonparalyzed mice form antibodies which are able to increase the rate of both junctional and extrajunctional AChR degradation, the mere presence of antibodies reactive with cell surface antigenic determinants of AChR is not sufficient for the induction of paralysis. While it is still possible that antibody-induced degradation of AChR may be necessary for the induction of paralysis, these studies rule out the possibility that antigenic modulation of AChR is sufficient to account for the induction of paralysis in mouse EMG. In the present studies alleles of the two loci were identified which significantly effect the probability with which mice immunized with AChR can be expected to become paralyzed, the MHC and the IgCH region. Because one genotype, H-2b, Ig-1b segregated with high susceptibility to EMG in four strains derived from three dissimilar backgrounds, these studies strongly suggest that susceptibility to the development of paralysis is a heritable trait determined by regions of the mouse genome which regulate immune responsiveness." @default.
• W2000560437 created "2016-06-24" @default.
• W2000560437 creator A5045072394 @default.
• W2000560437 creator A5062370984 @default.
• W2000560437 creator A5062506558 @default.
• W2000560437 creator A5067630038 @default.
• W2000560437 creator A5089825041 @default.
• W2000560437 date "1981-12-01" @default.
• W2000560437 modified "2023-10-16" @default.
• W2000560437 title "FACTORS AFFECTING THE SUSCEPTIBILITY OF DIFFERENT STRAINS OF MICE TO EXPERIMENTAL MY ASTHENIA GRAVIS" @default.
• W2000560437 cites W1597280377 @default.
• W2000560437 cites W1965280829 @default.
• W2000560437 cites W1977454658 @default.
• W2000560437 cites W197760010 @default.
• W2000560437 cites W1980226127 @default.
• W2000560437 cites W1983468718 @default.
• W2000560437 cites W1997579822 @default.
• W2000560437 cites W2004704893 @default.
• W2000560437 cites W2007474315 @default.
• W2000560437 cites W2014289724 @default.
• W2000560437 cites W2016956625 @default.
• W2000560437 cites W2018252071 @default.
• W2000560437 cites W2025673685 @default.
• W2000560437 cites W2026517249 @default.
• W2000560437 cites W2028198816 @default.
• W2000560437 cites W2032813616 @default.
• W2000560437 cites W2034606843 @default.
• W2000560437 cites W2050082684 @default.
• W2000560437 cites W2054633517 @default.
• W2000560437 cites W2057033206 @default.
• W2000560437 cites W2057780554 @default.
• W2000560437 cites W2062317639 @default.
• W2000560437 cites W2068136739 @default.
• W2000560437 cites W2068937042 @default.
• W2000560437 cites W2079351592 @default.
• W2000560437 cites W2079507892 @default.
• W2000560437 cites W2082991597 @default.
• W2000560437 cites W2083870276 @default.
• W2000560437 cites W2087265319 @default.
• W2000560437 cites W2119152348 @default.
• W2000560437 cites W2122768573 @default.
• W2000560437 cites W2125213900 @default.
• W2000560437 cites W2130637392 @default.
• W2000560437 cites W2158055057 @default.
• W2000560437 cites W2244950998 @default.
• W2000560437 cites W2399457679 @default.
• W2000560437 cites W2500437335 @default.
• W2000560437 doi "https://doi.org/10.1111/j.1749-6632.1981.tb33736.x" @default.
• W2000560437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6951476" @default.
• W2000560437 hasPublicationYear "1981" @default.
• W2000560437 type Work @default.
• W2000560437 sameAs 2000560437 @default.
• W2000560437 citedByCount "20" @default.
• W2000560437 crossrefType "journal-article" @default.
• W2000560437 hasAuthorship W2000560437A5045072394 @default.
• W2000560437 hasAuthorship W2000560437A5062370984 @default.
• W2000560437 hasAuthorship W2000560437A5062506558 @default.
• W2000560437 hasAuthorship W2000560437A5067630038 @default.
• W2000560437 hasAuthorship W2000560437A5089825041 @default.
• W2000560437 hasConcept C105702510 @default.
• W2000560437 hasConcept C126322002 @default.
• W2000560437 hasConcept C134018914 @default.
• W2000560437 hasConcept C141071460 @default.
• W2000560437 hasConcept C147483822 @default.
• W2000560437 hasConcept C159654299 @default.
• W2000560437 hasConcept C163764329 @default.
• W2000560437 hasConcept C169760540 @default.
• W2000560437 hasConcept C170493617 @default.
• W2000560437 hasConcept C203014093 @default.
• W2000560437 hasConcept C24998067 @default.
• W2000560437 hasConcept C2776418732 @default.
• W2000560437 hasConcept C2776532573 @default.
• W2000560437 hasConcept C2777240379 @default.
• W2000560437 hasConcept C2778105408 @default.
• W2000560437 hasConcept C2779618896 @default.
• W2000560437 hasConcept C2780247198 @default.
• W2000560437 hasConcept C54355233 @default.
• W2000560437 hasConcept C71924100 @default.
• W2000560437 hasConcept C80161118 @default.
• W2000560437 hasConcept C86803240 @default.
• W2000560437 hasConceptScore W2000560437C105702510 @default.
• W2000560437 hasConceptScore W2000560437C126322002 @default.
• W2000560437 hasConceptScore W2000560437C134018914 @default.
• W2000560437 hasConceptScore W2000560437C141071460 @default.
• W2000560437 hasConceptScore W2000560437C147483822 @default.
• W2000560437 hasConceptScore W2000560437C159654299 @default.
• W2000560437 hasConceptScore W2000560437C163764329 @default.
• W2000560437 hasConceptScore W2000560437C169760540 @default.
• W2000560437 hasConceptScore W2000560437C170493617 @default.
• W2000560437 hasConceptScore W2000560437C203014093 @default.
• W2000560437 hasConceptScore W2000560437C24998067 @default.
• W2000560437 hasConceptScore W2000560437C2776418732 @default.
• W2000560437 hasConceptScore W2000560437C2776532573 @default.
• W2000560437 hasConceptScore W2000560437C2777240379 @default.
• W2000560437 hasConceptScore W2000560437C2778105408 @default.
• W2000560437 hasConceptScore W2000560437C2779618896 @default.
• W2000560437 hasConceptScore W2000560437C2780247198 @default.
• W2000560437 hasConceptScore W2000560437C54355233 @default.

• next