FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000560762> ?p ?o ?g. }

• W2000560762 abstract "Abstract The classical myeloproliferative disorders (MPDs) of essential thrombocythemia, polycythemia vera, and primary myelofibrosis have an increasing predisposition to transform to overt acute leukemia or MPD-blast phase (MPD-BP). Current therapies for the MPDs are limited, and no therapy other than allogeneic stem cell transplantation (alloSCT) has clearly altered the natural history of these disorders. Pathogenetic mechanisms that lead to an MPD progressing to MPD-BP are incompletely understood but seem to correlate with the accumulation of additional karyotypic abnormalities as opposed to increases in MPD-associated molecular lesion burden (such as JAK2V617F). The development of MPD-BP is heralded by worsening cytopenias, constitutional symptoms, and a poor survival despite therapeutic intervention. Risk factors for developing MPD-BP include features at diagnosis (such as increased peripheral blood blasts, karyotypic abnormalities, and thrombocytopenia) and exposure to established agents that enhance leukemogenesis (ie, P-32 and alkylators). Multiple avenues of therapeutic investigation are ongoing to treat or prevent MPD-BP, including early alloSCT, hypomethylating agents, and JAK2 inhibition. An improved understanding of the pathogenetic underpinnings of MPD-BP are necessary if more effective targeted therapies are to be developed." @default.
• W2000560762 created "2016-06-24" @default.
• W2000560762 creator A5039057642 @default.
• W2000560762 date "2008-11-01" @default.
• W2000560762 modified "2023-09-26" @default.
• W2000560762 title "Acute Leukemia Arising from the Myeloproliferative Disorders: Challenge and Opportunity" @default.
• W2000560762 cites W1421162947 @default.
• W2000560762 cites W1446966563 @default.
• W2000560762 cites W1581000033 @default.
• W2000560762 cites W1980568348 @default.
• W2000560762 cites W2008952929 @default.
• W2000560762 cites W2015506962 @default.
• W2000560762 cites W2015662674 @default.
• W2000560762 cites W2025606645 @default.
• W2000560762 cites W2025754007 @default.
• W2000560762 cites W2027138297 @default.
• W2000560762 cites W2028961479 @default.
• W2000560762 cites W2035626929 @default.
• W2000560762 cites W2038488698 @default.
• W2000560762 cites W2039956148 @default.
• W2000560762 cites W2045542032 @default.
• W2000560762 cites W2047079894 @default.
• W2000560762 cites W2049145190 @default.
• W2000560762 cites W2054753195 @default.
• W2000560762 cites W2055386534 @default.
• W2000560762 cites W2056116861 @default.
• W2000560762 cites W2056777053 @default.
• W2000560762 cites W2057360098 @default.
• W2000560762 cites W2058330063 @default.
• W2000560762 cites W2070492834 @default.
• W2000560762 cites W2082274795 @default.
• W2000560762 cites W2091165956 @default.
• W2000560762 cites W2096638244 @default.
• W2000560762 cites W2106788103 @default.
• W2000560762 cites W2112316414 @default.
• W2000560762 cites W2116043577 @default.
• W2000560762 cites W2129629467 @default.
• W2000560762 cites W2131637500 @default.
• W2000560762 cites W2143139581 @default.
• W2000560762 cites W2144664431 @default.
• W2000560762 cites W2146505525 @default.
• W2000560762 cites W2147182596 @default.
• W2000560762 cites W2300648760 @default.
• W2000560762 cites W2312804644 @default.
• W2000560762 cites W2315963229 @default.
• W2000560762 cites W2530515023 @default.
• W2000560762 cites W2539951857 @default.
• W2000560762 cites W2550114143 @default.
• W2000560762 cites W2550635809 @default.
• W2000560762 cites W2552564416 @default.
• W2000560762 cites W2558010576 @default.
• W2000560762 cites W2564620653 @default.
• W2000560762 cites W2586976950 @default.
• W2000560762 cites W2588005189 @default.
• W2000560762 cites W2979398211 @default.
• W2000560762 cites W2980774160 @default.
• W2000560762 cites W3114368461 @default.
• W2000560762 doi "https://doi.org/10.3816/clk.2008.n.034" @default.
• W2000560762 hasPublicationYear "2008" @default.
• W2000560762 type Work @default.
• W2000560762 sameAs 2000560762 @default.
• W2000560762 citedByCount "0" @default.
• W2000560762 crossrefType "journal-article" @default.
• W2000560762 hasAuthorship W2000560762A5039057642 @default.
• W2000560762 hasConcept C126322002 @default.
• W2000560762 hasConcept C143998085 @default.
• W2000560762 hasConcept C203014093 @default.
• W2000560762 hasConcept C2776863199 @default.
• W2000560762 hasConcept C2778461978 @default.
• W2000560762 hasConcept C2778837598 @default.
• W2000560762 hasConcept C2780007613 @default.
• W2000560762 hasConcept C2780076729 @default.
• W2000560762 hasConcept C2781057849 @default.
• W2000560762 hasConcept C2910274570 @default.
• W2000560762 hasConcept C2911091166 @default.
• W2000560762 hasConcept C71924100 @default.
• W2000560762 hasConceptScore W2000560762C126322002 @default.
• W2000560762 hasConceptScore W2000560762C143998085 @default.
• W2000560762 hasConceptScore W2000560762C203014093 @default.
• W2000560762 hasConceptScore W2000560762C2776863199 @default.
• W2000560762 hasConceptScore W2000560762C2778461978 @default.
• W2000560762 hasConceptScore W2000560762C2778837598 @default.
• W2000560762 hasConceptScore W2000560762C2780007613 @default.
• W2000560762 hasConceptScore W2000560762C2780076729 @default.
• W2000560762 hasConceptScore W2000560762C2781057849 @default.
• W2000560762 hasConceptScore W2000560762C2910274570 @default.
• W2000560762 hasConceptScore W2000560762C2911091166 @default.
• W2000560762 hasConceptScore W2000560762C71924100 @default.
• W2000560762 hasLocation W20005607621 @default.
• W2000560762 hasOpenAccess W2000560762 @default.
• W2000560762 hasPrimaryLocation W20005607621 @default.
• W2000560762 hasRelatedWork W160671777 @default.
• W2000560762 hasRelatedWork W199274643 @default.
• W2000560762 hasRelatedWork W2015352587 @default.
• W2000560762 hasRelatedWork W2020309957 @default.
• W2000560762 hasRelatedWork W2029944177 @default.
• W2000560762 hasRelatedWork W2052269104 @default.
• W2000560762 hasRelatedWork W2053528807 @default.
• W2000560762 hasRelatedWork W2090253116 @default.
• W2000560762 hasRelatedWork W2127361094 @default.

• next