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- W2000561207 abstract "Human skeletal muscle contains three types of the main motor protein myosin heavy chain (MHC) and individual muscle fibers contain only one type of MHC (pure fiber types: I, IIa and IIx) or a mixture of MHC (hybrid fiber types: I/IIa and IIa/IIx). Each of these fiber types has a distinct phenotypic profile that contributes to human locomotion. The mixture of these fiber types within the muscle can have a profound impact on athletic performance. Our laboratory recently had the opportunity to examine the skeletal muscle profile of a World Record holder and World Champion sprint runner. PURPOSE: To examine single muscle fiber MHC composition (i.e. fiber type) and single muscle fiber contractile function (strength, speed and power) from this World Class sprinter. METHODS: A large number of isolated single muscle fibers from the vastus lateralis were analyzed for contractile function (n=53) and fiber type profile (n=329 fibers). RESULTS: Fiber type profile showed that 72% of the muscle contained fast motor proteins (MHC IIa and IIx). The novel finding was that the sprint champion's muscle contained 24% of the pure MHC IIx fiber type. Normal healthy human adult muscle contains less than 2% of the pure MHC IIx fiber type. Power output of the MHC IIx muscle fibers were the highest values recorded to date by a wide margin (35±4 W·l-1). Single fiber power output data from other athletic populations (swimmers and distance runners) and recreational athletes generally fall in the range of 5-10 W·l-1 and do not exceed 20 W·l-1. CONCLUSION: The unusually high abundance and high power output of the rare and powerful pure MHC IIx fiber type represent a unique muscle signature that provides a myocellular basis for the high level of athletic success achieved in sprinting events by this individual." @default.
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- W2000561207 date "2010-05-01" @default.
- W2000561207 modified "2023-09-26" @default.
- W2000561207 title "Skeletal Muscle Signature of a Champion Sprint Runner" @default.
- W2000561207 doi "https://doi.org/10.1249/01.mss.0000384705.59340.1f" @default.
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